Oxidative Stress & Disease The Metabolic-Inflammatory Axis in Brain Aging and Alzheimer's Disease

The 2013 GRC on Oxidative Stress and Disease, "The Metabolic Inflammatory Axis in Brain Aging and Alzheimer’s Disease", focuses on bioenergetic deficits, activation of inflammatory responses, and white matter metabolism in brain aging and Alzheimer’s. Dynamic interactions among these systems will be examined in terms of their causative or in-tandem occurrence and whether they occur in micro-environments that ultimately lead to global changes in brain. The themes of the conference are integrated in 9 sessions that include (a) Neurovascular and neurometabolic pathways in brain aging and Alzheimer’s disease; (b) Mitochondrial metabolism in brain aging and neurodegeneration; (c) functional metabolic parameters of brain aging and cognition; (d) Neuroinflammation, microglia aging, and Alzheimer’s disease; (f) Insulin resistance, diabetes, and the risk of Alzheimer’s disease; (g) Systemic environment in brain aging and Alzheimer’s, and (h) Age-related cognitive deficits. Two other sessions include a keynote presentation and oral presentations from young investigators from selected poster.

The Conference will bring together a distinguished cadre of investigators who are at the forefront of their field, and will provide opportunities for junior scientists and graduate students to present their work in poster format and exchange ideas with leaders in the field. Some poster presenters will be selected for short talks. The collegial atmosphere of this Conference, with programmed discussion sessions as well as opportunities for informal gatherings in the afternoons and evenings, provides an avenue for scientists from different disciplines to brainstorm and promotes cross-disciplinary collaborations in the various research areas represented.

+ show speakers and program
Keynote Lecture
Discussion Leader: TBA

Roberta D. Brinton: Sex Differences in Bioenergetic Aging of Brain and Risk of Alzheimer's Disease

Neurovascular and Neurometabolic Pathways in Brain Aging and Alzheimer's Disease
Discussion Leader: José Viña

Joao Laranjinha: Neurovascular and neurometabolic uncoupling in brain aging and neurodegeneration: a vascular nitric oxide-driven redox hypothesis
Helena Chui: Vascular risk factors and Alzheimer's disease
Berislav V. Zlokovic: Blocade of receptor of advanced glycation end products at the BBB normalizes cognitive function

Mitochondrial Metabolism in Brain Aging and Neurodegeneration
Discussion Leader: LaDora Thompson

Russell H. Swerdlow: Brain aging, Alzheimer's disease, and mitochondria
Antonio Zorzano: Mitochondrial dynamics and its implications in metabolic dysregulation and neurodegeneration
David C. Rubinsztein: Control of autophagy as a therapy for neurodegenerative diseases

Functional Metabolic Parameters of Brain Aging and Cognition
Discussion Leader: Bertrand Friguet

Susan M. Resnick: MRI-based biomarkers of brain aging, resting state, and mild cognitive impairment
Gene L. Bowman: MIR measures of brain aging and nutrient biomarker patterns
Douglas L. Rothman: Altered brain mitochondrial metabolism in healthy aging as assessed by in vivo magnetic resonance spectroscopy
Rima Kaddurah-Daouk: Metabolomics in early Alzheimer's disease
Pierre Magistreti: Brain energy metabolism and aging: focus on astrocyte-neuron metabolic cooperation

Neuroinflammation, Microglia Aging, Brain Aging, and Alzheimer's Disease
Discussion Leader: Kelvin Davies

Marina A. Lynch: Age-related neuroinflammatory changes impact negatively on neuronal function
Agneta Nordberg: Inflmmatory changes (astrocytosis) in brain by PET at different stages of Alzheimer's disease
Linda J. van Eldik: Inflammatory cytokines and NFκB and MAPK-dependent pathways in Alzheimer's disease
Catarina Oliveira: Neuroinflammation and oxidative stress in brain aging and the pathogenesis of Alzheimer's
Rommy von Bernhardi: Redox dysregulation and inflammatory mechanisms mediated by microglia aging in Alzheimer's disease

Insulin Resistance, Diabetes, and the Risk of Alzheimer's Disease
Discussion Leader: Efstathios S. Gonos

Claudio Franceschi: Biological parameters remodeling during human aging: complex regulation in longevity and in diabetes
Susan Craft: Insulin resistance and pathological brain aging
Suzanne M. de la Monte: Brain insulin resistance and deficiency as therapeutic targets in Alzheimer's disease
Fernanda G. De Felice: IRS-1 inhibition and ER stress links impaired insulin signaling in Alzheimer's and type-2 diabetes: Protection by anti-diabetic agents

Systemic Environment in Brain Aging and Alzheimer's Disease
Discussion Leader: TBA

Tony Wyss-Coray: The systemic environment as a modulator of brain aging and Neurodegeneration
Gerald Münch: Association of peripheral AGE levels with cognitive decline
Mario F. Fraga: The role of epigenetics in aging and age-related diseases
Andrey P. Loboda: Molecular insights into the pathogenesis of Alzheimer's and its relationship to normal aging
Vittorio Calabrese: Redox regulation of cellular stress response in aging and neurodegenerative disorders: Role of vitagens

Young Investigator Presentations
Discussion Leaders: Rajiv Ratan, Deborah Ferrington

Age-Related Cognitive Deficits
Discussion Leader: TBA

William J. Jagust: Neural activity, β-amyloid, and Alzheimer's disease
Orly Lazarov: Misregulation of neurogenesis in aging and Alzheimer's disease: Implications for cognitive function
Olivier Thibault: Hippocampal and cognitive aging: bioenergetic shift precedes cholesterol trafficking
Giuseppe Poli: The link between altered cholesterol metabolism and Alzheimer's disease

14 Apr - 19 Apr 2013
meeting website