74th Harden Conference - Helicases and nucleic acid translocases

The study of helicases and translocases is a rapidly growing field, fuelled by the fact that helicase defects are associated with inherited human diseases including neurological disorders, cancer, and aging processes. Pathogens encode helicases, making these enzymes targets for new anti-viral or anti-bacterial therapies. New discoveries linking helicases to disease states are being discovered regularly, due to the fact that helicases and translocases participate in a wide variety of cellular functions. These include DNA replication, DNA repair, DNA recombination, transcription, ribosome biogenesis, translation, RNA splicing, RNA editing, RNA transport, RNA degradation, bacterial conjugation, chromosome segregation and viral packaging/unpackaging.

The biological importance of these motor enzymes is now very clear and new potential helicases and translocases are reported routinely in the literature. "Helicases and nucleic acid translocases" follows on directly from previous meetings in an established and popular series which has been held biennially since 1999. The meeting will encourage participation by experts in a variety of disciplines, with an emphasis on using interdisciplinary approaches to understand molecular mechanisms.

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Anna Marie Pyle (Yale University, U.S.A.)
DEAD box helicase modules: variations of a common theme
Dagmar Klostermeier (University of Münster, Germany)
Dale Wigley (The Institute of Cancer Research, United Kingdom)
Structure of DNA-translocating Type I restriction enzymes
David Dryden (University of Edinburgh, United Kingdom)
Molecular Mechanism and Cellular Functions of the DEAD-box RNA Helicase Ded1p
Eckhard Jankowsky (Case Western Reserve University, U.S.A.)
TrwB: a molecular motor involved in DNA transfer during bacterial conjugation
Elena Cabezon (Universidad de Cantabria, Spain)
Title: Pif1 family helicases affect genome stability in diverse ways
Ginger Zakian (Princeton University, U.S.A.)
The Exon Junction Complex and its RNA helicases
Hervé Le Hir (Institut de Biologie de l’École Normale Supérieure (IBENS) , France)
Structural mechanisms of ring-ATPases
James Berger (University of California, Berkeley, U.S.A.)
Structural mechanisms of DNA replication restart
James Keck (University of Wisconsin, Madison, U.S.A.)
Karsten Weis (University of California, Berkeley, U.S.A.)
Laurie Kaguni (Michigan State University, U.S.A.)
Maria Falkenberg (University of Gothenburg, Sweden)
Pro- and anti-recombinogenic activities of FBH1 helicase one molecule at a time
Maria Spies (University of Illinois, Urbana-Champaign, U.S.A.)
How specific sequences modulate AddAB helicase-nuclease during translocation along DNA
Mark Dillingham (University of Bristol, United Kingdom)
Nigel Savery (University of Bristol, United Kingdom)
From unwinding to clamping - the DEAD box RNA helicase family
Patrick Linder (University of Geneva, Sweden)
Role of the conserved Pif1 helicase in homologous recombination
Patrick Sung (Yale University, U.S.A.)
Regulating helicase function at the replication fork
Peter McGlynn (University of Aberdeen, United Kingdom)
Rick Russell (University of Texas at Austin, U.S.A.)
G-quadruplex structures in the genome
Shankar Balasubramanian (University of Cambridge, United Kingdom)
Sheila Stewart (Washington University School of Medicine, U.S.A.)
Smita Patel (UMDNJ-Robert Wood Johnson Medical School, U.S.A.)
The archaeal Cdc45•MCM•GINS replicative helicase complex
Stephen Bell (Indiana University at Bloomington, U.S.A.)
Watching individual DNA helicases and motor proteins: unexpected un-twists and turns
Stephen Kowalczykowski (University of California, Davis, U.S.A.)
DNA unwinding and translocation by E. coli RecBCD helicase
Timothy Lohman (Washington University School of Medicine, U.S.A.)
ATP-dependent chromatin remodelling enzymes
Tom Owen-Hughes (University of Dundee, United Kingdom)
Molecular mechanisms of CRISPR systems
Virginijus Siksnys (Vilnius University, Lithuania)
Regulation of recombinational DNA repair
Wolf-Dietrich Heyer (University of California, Davis, U.S.A.)
Xiaodong Zhang (Imperial College London, United Kingdom)

4 Aug - 8 Aug 2013
United Kingdom
meeting website