Single Molecule Approaches to Biology

This conference aims to provide an interdisciplinary forum for biologists, physicists, chemists and engineers who have developed single molecule methodologies that can be readily applied to solve important biological problems. This emerging field of science attracts a young cohort of scientists who get a chance to interact closely with established leaders, promoting a creative environment of inquiry that greatly advances the field.

Early efforts of the single molecule community were almost entirely focused on developing new techniques. Now, and in large part due to this conference, single molecule techniques are rapidly occupying a central role in biological research at all levels. This transition was made possible by the availability and dissemination of robust techniques that use fluorescence and force probes to track the conformation of molecules one at a time, in vitro as well as in live cells. Single-molecule approaches have changed the way many biological problems are studied. These novel techniques provide previously unobtainable data on fundamental biochemical processes that are essential for all forms of life. The ability of single-molecule approaches to avoid ensemble averaging and to capture transient intermediates and heterogeneous behavior renders them particularly powerful in elucidating mechanisms of the molecular systems that underpin the functioning of living cells. Hence, our conference seeks to disseminate the implementation and use of single molecule techniques in the pursuit of new biological knowledge. In addition, the conference provides for a modern training ground for young scientists that wish to learn how to conduct interdisciplinary research.
+ show speakers and program
Timothy Springer (Harvard University)
"Single molecule studies on the arterial shear sensor protein von Willebrand factor"
Joseph D. Puglisi (Stanford University)
Robert T. Sauer (Massachusetts Institute of Technology)
Silvio Rizzoli (European Neuroscience Institute)
David Rueda (Wayne State University)
Ruben Gonzalez (Columbia University)
Johan Elf (University of Uppsala)
Carlos Bustamante (UC Berkeley)
Yale Goldman (University of Pennsylvania)
Sergi Garcia-Manyes (Kings College London)
Jeff Gelles (Brandeis University)
Holger Stark (Max Planck Institute for Biophysical Chemistry)
Toshio Yanagida (Osaka University, Keynote lecturer)
Eric Greene (Columbia University)
"Visual Biochemistry: Single Molecule Imaging of Protein-DNA Interactions"
Matthias Rief (Technical University Munich)
Xiaowei Zhuang (Harvard University)
Petra Schwille (Technical University Dresden)
Sunney Xie (Harvard University)
Steven Block (Stanford University)
Jörg Wrachtrup (Universität Stuttgart)
Olga Dudko (UC San Diego)
"Theory and interpretation of single molecule force experiments"
Yossi Klafter (Tel Aviv University)
Viola Vogel (ETH Zürich)
"How cells exploit mechanical aspects of single molecules"
Helmut Grubmuller (Max Planck Institute for Biophysical Chemistry)
Martin Karplus (Harvard University, Keynote lecturer)

Discussion Leaders:

Shimon Weiss (UC Los Angeles)
Kevin Plaxco (UC Santa Barbara)
Taekjip Ha (UIUC)
Hermann Gaub (LMU, Munich)
Michelle Wang (Cornell University)

15 Jul - 20 Jul 2012
West Dover
United States of America
meeting website