Hormone-Dependent Cancers, Development and Progression

The Gordon Research Conference (GRC), focused on Hormone-Dependent Cancers: Development and Progression will be held on July 28th-August 2nd, 2013 at Bryant College in Rhode Island. Developing means to prevent and treat hormone-dependent cancers is of critical importance, give the significant impact these malignancies have on human health. Recent evidence suggests that hormones influence a large number of heretofore unappreciated processes associated with cancer development, including not only cell signaling and transcriptional regulation, but also aggressive tumor phenotypes (e.g. tumor cell dissemination, stem cell function, response to chemotherapy and DNA damaging agents, tumor metastasis, and alterations of the tumor microenvironment). It is also now clear that the role of hormones extends far beyond breast and prostate cancer, and that a multitude of both peptide and steroid hormones have a major impact on human malignancies not previously known to be hormone sensitive.

A thorough understanding of hormone action in regulating these cellular processes and cancer phenotypes is essential for the advancing understanding of hormone action in the most basic sense, translating these new findings into potential nodes for novel treatment strategies, and for coupling existing hormone associated therapies to new treatments. Toward this end, the 2013 GRC is designed to maximize interaction between the basic science test, investigators with expertise in chromatin regulation, transcription control, cell signaling, translational scientists with expertise in modeling human disease, and physician scientists who stand at the forefront of improving treatment for hormone dependent malignancies. The goal of the 2013 GRC will be to provide a format for this necessary interaction and fruitful exchange of scientific ideas common to overlapping research fields, such that novel concepts emerge, scientific collaborations are formed, and new translational opportunities are revealed.
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Preliminary Program
The detailed program is currently being developed by the Conference Chair and will be available by March 28, 2013. Please check back for updates.

Hormone Action and Cancer Development
(Karen Knudsen / Charles Perou [keynote] / Gail Prins / Geoffrey Greene)
Chromatin Regulation in Cancer Development and Progression: Seq and You Will Find...
(Vasan Yegnasubramanian, Geoffrey Greene / Peter Jones / W. Lee Kraus / Carol Lange / Edwin Cheung)
Cross Talk of Hormone Receptor and DNA Damage Response Pathways
(Edwin Cheung, Steve Balk / Vasan Yegnasubramanian / Felix Feng / Helen Piwnica-Worms)
Stem Cells and Cancer Development
(Gail Prins, Carol Lange / Geoffrey Lindeman / Dean Tang / Michael Shen)
Microenvironment and Metastasis
(Elahe Mostaghel / Gail Risbridger / Kornelia Polyak / Nora Navone / Theresa Hickey)
Endocrine Therapy Resistance
(Robert Clarke, Gail Risbridger / Howard Scher / Joyce Slingerland / Leonie Young / Stephen Plymate)
Hormone Action in Cancers Beyond Breast and Prostate
(Michael Shen, Joyce Slingerland / Cheryl Walker / Jill Siegfried / Elahe Mostaghel)
Hormones in Translation
(Wayne Tilley / Johann deBono [keynote] / Jason Carroll / Cliff Hudis / Steve Balk)
The Future of Targeted Therapy
(Felix Feng, Leonie Young / Ganesh Raj / Robert Clarke / Charis Eng)

28 Jul - 2 Aug 2013
United States of America
meeting website