Europhosphatase 2013: Protein Phosphatases in Health and Disease

EMBO Conference on "Europhosphatase 2013: Protein Phosphatases in Health and Disease" focuses on the structure, function, regulation, and physiological roles of protein phosphatases. Protein phosphatases perform specific roles in discrete signaling pathways and play major roles in regulating the functions of proteins, cells, and organisms. Improper phosphatase activity has been linked to many diseases, including cancer, neurologic disease, diabetes, and obesity. Phosphatases are thus appealing potential targets for pharmaceutical intervention.
The meeting will include sessions on:
Phosphatase structure and regulation.
Subcellular functions of protein phosphatases.
Phosphatases in development.
Phosphatases in the nervous system.
Phosphatases in cancer.
Phosphatases in diabetes and the metabolic syndrome.
A special “hot topic” session: Phosphatases and Drug Development.
Proteomics-based studies of phosphatases.
+ show speakers and program


15:00-18:30 Registration at meeting site

Session 1: Keynote Lecture

18:30-19:45 Gerard Karsenty, USA: The discovery of an endocrine function of bone through a phosphatase.
19:45-22:00 Reception and Dinner


Session 2: Phosphatases in development

09:00-09:30 Anton Bennett, USA: Mechanisms of MAP Kinase Phosphatases in Disease
09:30-10:00 Maria Kontaridis, USA: Role of SHP2 in systemic lupus erythematosus
10:00-10:30 Two talks from selected abstracts
10:30-11:00 Coffee break
11:00-11:30 Jeroen den Hertog, The Netherlands: Protein-tyrosine phosphatases in zebrafish development
11:30-12:00 Egon Ogris, Austria: Regulation of PP2A biogenesis
12:00-12:30 Two talks from selected abstracts
12:45-14:15 Lunch

Session 3: Cancer signaling

14:15-14:45 William Hahn, USA: Functional genomics, PP2A and cancer
14:45-15:15 Yosef Yarden, Israel: Negative regulation of RTKs: relevance to tumor progression
15:15-15:45 Two talks from selected abstracts
15:45-16:15 Coffee break
16:15-16:45 Alexander Levitzki, Israel: Tyrosine phosphorylation inhibitors (tyrphostins): Their clinical performance and how to improve targeted therapy
16:45-17:15 Besim Ogretmen, USA: Mechanisms of PP2A activation by sphingosine analogue drug FTY720 leading to lung cancer necroptosis
17:15-17:45 Jukka Westermarck, Finland: Reactivation of protein phosphatase 2A (PP2A) as a multi-target strategy for cancer therapy
18:00-19:30 Poster session I
19:30-22:00 Dinner


Session 4: Phosphatases in neurobiology

09:00-09:30 Sheila Harroch, France: Receptor tyrosine phosphatase deficient mice: models for CNS diseases
09:30-10:00 Isabelle Mansuy, Switzerland: Epigenetic regulation by PP1 for memory formation
10:00-10:30 Two talks from selected abstracts
10:30-11:00 Coffee break
11:00-11:30 Angus Nairn, USA: Beyond the Dopamine Receptor: Roles and Regulation of Serine/Threonine Protein Phosphatases PP1 and PP2A in Neuronal Signaling
11:30-12:00 Catherine Pallen, Canada: (TBA)
12:00-12:30 Two talks from selected abstracts
12:45-14:15 Lunch

Session 5: Regulation of phosphatase function

14:15-14:45 Nicholas Tonks, USA: (TBA)
14:45-15:15 Tzu-Ching Meng (Taiwan): Visualization of S-nitrosylated PTP1B reveals the essential role of nitric oxide in endothelial insulin responsiveness
15:15-15:45 Two talks from selected abstracts
15:45-16:15 Coffee break
16:15-16:45 Arne Ostman, Sweden: Regulation of reversible PTP oxidation
16:45-17:15 Jin Zhang, USA: Spatiotemporal Regulation of Kinases and Phosphatases in Living Cells
17:15-17:45 Two talks from selected abstracts
18:00-19:30 Poster session II
19:30-22:00 Dinner


Session 6: Subcellular functions of phosphatases-I

09:00-09:30 David Virshup, Singapore: Protein Phosphatase 2A in control of cell proliferation
09:30-10:00 Tamar Kleinberger, Israel: Targeting PP2A by the adenovirus E4orf4 protein: benefits for virus infection and cell-death induction
10:00-10:30 Two talks from selected posters
10:30-11:00 Coffee Break
11:00-11:30 Geraldine Seydoux, USA: Role of PP2A phosphatase in cell polarization
11:30-12:00 Zhong-Yin Zhang, USA: Functional analysis of PRL phosphatases
12:00-12:30 Sara Lavi, Israel: (TBA)
12:45-14:00 Lunch
14:00 - onwards Free Afternoon. Optional tour of Old Jerusalem.


Session 7: Subcellular functions of phosphatases-II

09:00-09:30 Mathieu Bollen, Belgium: Regulation of mitotic chromosome targeting of PP1 and PP2A
09:30-10:00 Xing Guo, USA: UBLCP1: Putting a leash on nuclear proteasomes by taking off phosphates
10:00-10:30 Two talks from selected posters
10:30-11:00 Coffee Break

Session 8: Special session - Phosphatase drug development

11:00-11:30 Nicholas Tonks, USA: (TBA)
11:30-12:00 Zhong-Yin Zhang, USA: Drugging the undruggable: targeting protein tyrosine phosphatases for therapeutic development
12:00-12:30 Jon Read, UK: Industrial Perspectives on Phosphatases as Drug Targets
12:30-13:00 Discussion
13:00-14:30 Lunch

Session 9: Phosphatases in metabolism

14:30-15:00 Tony Tiganis, Australia: PTPs, ROS & insulin sensitivity
15:00-15:30 Gen-Sheng Feng, USA: Shp2 in Liver Metabolism, Disorders and Tumorigenesis
15:30-16:00 Michel Tremblay, Canada: The phosphatomes in cancer and metabolism
16:00-16:30 Coffee Break
16:30-17:00 Anne-Claude Gingras: Evolution of phosphatase interactomes
17:00-17:30 Benjamin Neel, Canada: Shp2 in health and disease
17:30-17:45 Business meeting
18:00-18:30 Break

Session 10: Keynote Lecture:

18:30-19:45 Yosef Shiloh, Israel: The ATM-mediated phosphorylation-dephosphorylation cascade in response to DNA damage: robust, but finely tuned
19:45-onwards Gala Dinner, best poster awards

FRIDAY, 12 JULY 2013

Departure from Rehovot

7 Jul - 12 Jul 2013
meeting website