Nuclear Receptors: Biological Networks, Genome Dynamics and Disease

Nuclear receptors (NRs) represent a large superfamily of transcription factors that function as ligand-dependent sensors for a diverse set of fat-soluble hormones, vitamins and dietary lipids. Together, NRs govern expression of genes involved in a broad range of reproductive, developmental, metabolic and immune response programs. For this reason, NRs have been investigated for over 20 years as promising targets for drugs to treat a multitude of therapeutic indices, including cancer, diabetes, obesity, cardiovascular disease, hypertension, inflammation and cholestasis. However, despite the success of numerous NR-based therapies, there remain significant hurdles exploiting NRs to develop newer classes of therapies that achieve targeted benefits with reduced side effects. Thus, understanding the mechanisms, transcriptional targets and networks of physiologic pathways that govern NR action has become an important new strategy for evaluating the role of NRs in health and disease. This effort is now beginning to produce exciting new avenues of research in the field. This meeting will bring together a key group of junior and senior investigators that are exploring these new directions and provide participants with a matrix of unique possibilities for them to investigate in both academic and pharmaceutical laboratory settings.
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B. Franklin Pugh, Pennsylvania State University, USA
ChIP-exo: Precision Genome-Wide Mapping of Transcription Factors

Myles Brown, Dana Farber Cancer Institute, USA
Nuclear Receptor Cistromics

Christopher K. Glass, University of California, San Diego, USA
Inflammatory Remarks and NR Responses

Michael J. Garabedian, New York University School of Medicine, USA
Combinatorial Regulation of Neuronal Gene Expression by Glucocorticoids and BDNF

Kevin P. White, University of Chicago, USA
Mining NR Networks to Predict and Control Gene Regulation in Cancer

Benita S. Katzenellenbogen, University of Illinois at Urbana-Champaign, USA
Integrative Genomics of Gene and Metabolic Regulation by Estrogen Receptors and Collaborating Proteins in Breast Cancer—Response to Therapies and Resistance

Michael A. Mancini, Baylor College of Medicine, USA
Visualizing Mechanisms of Nuclear Receptor Function by Quantitative High Throughput Imaging

Johan Auwerx, École Polytechnique Fédérale de Lausanne (EPFL), Switzerland
Regulation of Mitochondrial Function and Aging

Bert W. O'Malley, Baylor College of Medicine, USA
Coactivators and Chromatin: Molecular Mechanisms and... New Therapies?

Donald P. McDonnell, Duke University Medical Center, USA
Moving from Empirical to Mechanism-based Discovery Approaches in the Search for Clinically Useful Nuclear Receptor Modulators

Inez Rogatsky, Weill Medical College of Cornell University, USA
Getting a GRIP on Gene Regulation

Michael R. Stallcup, University of Southern California, USA
Molecular and Physiological Roles of Coregulators in Transcriptional Regulation by Steroid Hormone Receptors

Gordon L. Hager, NCI, National Institutes of Health, USA
Nuclear Receptors and the Chromatin Landscape

Ueli Schibler, University of Geneva, Switzerland
Gene's Got Rhythm!

W. Lee Kraus, University of Texas Southwestern Medical Center, USA
Characterizing the Estrogen-Regulated Transcriptome

Peter Tontonoz, HHMI/University of California, Los Angeles, USA
Control of Lipid Metabolism by LXR Gates Inflammatory Signaling

Jason S. Carroll, Cancer Research UK, UK
Understanding Estrogen Receptor Transcription in Breast Cancer

Philip W. Shaul, University of Texas Southwestern Medical Center, USA
Estrogen Receptors and Cardiometabolic Health and Disease: Location, Location, Location

Sheue-Yann Cheng, NCI, National Institutes of Health, USA
Role of Corepressors in TR Mutant Actions in vivo

Susanne Mandrup, University of Southern Denmark, Denmark
Nuclear Receptor Networks in Adipogenesis

David J. Mangelsdorf, HHMI/University of Texas Southwestern Medical Center, USA
Nuclear Receptor/FGF Endocrine Signaling Pathways

Ronald M. Evans, HHMI/The Salk Institute, USA
Nuclear Receptors and the Hunger Games: From Feast to Famine

Orla M. Conneely, Baylor College of Medicine, USA
NR4As in Hematopoietic Stem Cell Development

Karen E. Knudsen, Thomas Jefferson University, Kimmel Cancer Center, USA
Controlling AR in Prostate Cancer: The SAGA Continues

Elisabeth D. Martinez, University of Texas Southwestern Medical Center, USA
Don't Ju Wanna Know about Jumonji?

Adriana Maggi, University of Milan, Italy
Estrogens and the Indissoluble Link Between Energy Metabolism and Reproduction

Mitchell A. Lazar, University of Pennsylvania School of Medicine, USA
Novel Physiological Functions of Nuclear Receptors

10 Jan - 15 Jan 2014
United States of America
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