Aging - Pushing the Limits of Cellular Quality Control

Organized by Andrew G. Dillin of University of California, Berkeley, Daniel E. Gottschling of Fred Hutchinson Cancer Research Center and Thomas Nyström of Göteborg University, the four-day conference will:
• Address fundamental gaps in our knowledge of cellular quality controls, an increasingly important area for aging research that also holds potential for identifying new therapies for Alzheimer’s, Parkinson’s and age-onset diabetes;
• Decipher the mechanisms of homeostatic control, its interconnective nature, and homeostatic communication between cells and organelles;
• Bridge interdisciplinary approaches studying different aspects of cellular quality control and homeostasis with more classical aging research in areas such as sirtuins and cellular senescence.

+ show speakers and program
Johan Auwerx, École Polytechnique Fédérale de Lausanne (EPFL), Switzerland
Genetics of Mitochondrial Metabolism

Adam Antebi, Max Planck Institute for Biology of Ageing, Germany
Enhanced Hexosamine Pathway Flux Extends Lifespan and Protects against Proteotoxicity

Benjamin Tu, UT Southwestern Medical Center at Dallas, USA
Acetyl-CoA as Metabolic Nexus: Metabolite, Sensor and Regulator

Gary Patti, Washington University, USA
Metabolomics as a Unique Biochemical Platform to Study Aging Pathways

Thomas Nyström, Göteborg University, Sweden
Factors Required for the Recognition, Partitioning and Asymmetrical Inheritance of Aggregates

Judith Frydman, Stanford University, USA
Distinct Compartments of Cytoplasmic Quality Control - iPOD and JUNQ

Joris Winderickx, KU Leuven, Belgium
Role of Vesicular Trafficking in Management of Folding Disease Proteins

Cole M. Haynes, Memorial Sloan-Kettering Cancer Center, USA
The Mitochondrial UPR

Jodi Nunnari, University of California, Davis, USA
Mitochondrial Behavior

Thomas Langer, University of Koeln, Germany
Proteolytic Control of Mitochondrial Dynamics

Norbert Perrimon, Harvard Medical School, USA
Mitochondrial Quality Control in Fly Aging

Thomas Kirkwood, Newcastle University, UK
The Evolvability of Stress Responses

Daniel E.L. Promislow, University of Georgia, USA
The Complexity Found between Cross Species Comparison of Quality Control

Adam Frost, University of Utah, USA
Functional Repurposing of Proteins through Evolution: How Organelle Homeostasis Mechanisms Vary Between Species

Miriam Greenberg, Wayne State University, USA
The Role of Mitochondrial Lipids in Cellular Processes

Lois S. Weisman, University of Michigan, USA
Inositol Phosphate Signaling, Protein Trafficking and Disease

Malene Hansen, Sanford-Burnham Medical Research Institute, USA
Autophagy and Lipid Metabolism

Richard I. Morimoto, Northwestern University, USA
HSF1 Regulation of Proteostasis

Jonathan S. Weissman, University of California, San Francisco, USA
Translation Accommodation as an Integrator of Aging

Bernd Bukau, Universität Heidelberg, Germany
Chaperone Mediated Translational Control

F. Ulrich Hartl, Max Planck Institut, Germany
The Toxicity of Protein Aggregation and the Cellular Defense Against It

Gerald S. Shadel, Yale University, USA
Mitochondrial-Stress Signaling Regulates Nuclear Gene Expression and Longevity

Daniel E. Gottschling, Fred Hutchinson Cancer Research Center, USA
Organelle Deterioration with Age: The Limits of an Interconnected Cellular System

Scott D. Emr, Cornell University, USA
Plasma Membrane Protein Quality Control: Essential Role for a Ubiquitin Ligase Adaptor Network

Andrew G. Dillin, University of California, Berkeley, USA
Proteostasis of Germ and Stem Cells

Yves P. Barral, ETH Zürich, Switzerland
Talk Title to be Determined

Mary-Rose Bufalino, University of Toronto, Canada
Stem Cell-Type Dependent Segregation of Protein Damage

Sean J. Morrison, HHMI/University of Texas Southwestern Medical Center, USA
The Rate of Protein Synthesis and the Maintenance of Long-Lived Cells

12 Jan - 17 Jan 2014
Steamboat Springs
United States of America
meeting website