Challenges and Opportunities in Diabetes Research and Treatment

Organized by Domenico Accili of Columbia University, Masato Kasuga of Kobe University Graduate School of Medicine and Morris F. White of Boston Children’s Hospital, Harvard Medical School, the conference will:
• Bring together scientists from academia, government and the pharmaceutical industry, to discuss the state of medical discovery in therapeutic areas most promising for the prevention, treatment and reversal of type 2 diabetes;
• Focus on topics such as increasing energy dispersal through
+ show speakers and program
Keynote Address
C. Ronald Kahn, Joslin Diabetes Center and Harvard Medical School, USA

Bruce M. Spiegelman, Harvard Medical School, USA
White, Brown, Beige and Brite: Toward a New Generation of Therapeutics for Metabolic Disease

Rebecca A. Haeusler, Columbia University, USA
Insulin, Bile Acids and Lipid Metabolism

Morris J. Birnbaum, University of Pennsylvania, USA
Metabolic Fluxes and Insulin Resistance

Kei Sakamoto, Nestle Institute of Health Sciences, Switzerland
Molecular Control of Hepatic Glycogenesis and Gluconeogenesis

Jonathan M. Graff, University of Texas Southwestern Medical Center, USA
Adipose Stem Cells: Give Me a Pill Not a Treadmill

Peter Arner, Karolinska Institute, Sweden
Bone Marrow as a Source of Adipocytes in Adult Humans

Matt Rodeheffer, Yale University, USA
Characterization of the Adipocyte Cellular Lineage in vivo

Lex H.T. Van der Ploeg, Rhythm Pharmaceuticals, USA
Melanocortin 4 Receptor Agonists for the Treatment of Obesity

David Maggs†, GI Dynamics, Inc., USA
Endobarrier Therapy for Obesity and Diabetes

Barbara Cannon, Stockholm University, Sweden
Brown Adipose Tissue and Thermogenesis

Joerg Heeren, University Medical Center Hamburg-Eppendorf, Germany
Brown Adipose Tissue and a Potential Role in Resolution of the Metabolic Syndrome

Masayuki Saito, Tenshi College, Japan
Regulation of the Activity of Human Brown Adipose Tissue

Antonio J. Vidal-Puig, University of Cambridge, UK
BMP8b and Thermogenesis

Lee M. Kaplan, Massachusetts General Hospital, USA
Molecular Mechanisms of Response to Roux-en-Y Gastric Bypass

Blandine Laferrère, St Luke's Roosevelt Hospital, Columbia University, USA
Mechanisms of Diabetes Remission after Gastric Bypass Surgery: Not Just Weight Loss

Carel Le Roux, University College Dublin, Ireland
GI Regulation of Appetitive Drives

Hans-Rudolf Berthoud, Pennington Biomedical Research Center, USA
Neural Mechanisms of Gastric Bypass

Avirup Bose, Novartis Institutes for Biomedical Research Inc., USA
Emergies Therapies for Type 2 Diabetes and Their Challenges

Anish Konkar, Hoffman-La Roche Inc., USA
Leveraging Gut Peptides for the Treatment of Type 2 Diabetes

Alessandro Pocai, Janssen, Pharmaceutical Companies of Johnson & Johnson, USA
Leveraging the Hypoglycemic Counterregulatory System to Treat Diabetes

Koji Takeuchi, Takeda Pharmaceutical Company Ltd., Japan
MOA and Pharmacological Profile of GPR40 Agonist, Fasiglifam

Richard B. Simerly, Children's Hospital Los Angeles, University of Southern California, USA
Hypothalamic Development

Kevin L. Grove, Oregon National Primate Research Center, USA
Effects of Maternal Overnutrition

Lori M. Zeltser, Columbia University, USA
Food Restriction and Hypothalamic Development

Tamas L. Horvath, Yale University School of Medicine, USA
Synaptic Plasticity

Sebastien G. Bouret, University of Southern California, USA
Molecular Mechanisms Involved in Hypothalamic Development

Morris F. White, Boston Children's Hospital, Harvard Medical School, USA
Diabetes, Huntington and Alzheimer

Linda Partridge, Max Planck Institute for Biology of Ageing, Germany
Genes Controlling Lifespan and Metabolism

Ana Maria Cuervo, Albert Einstein College of Medicine, USA
Age-Related Disease and Autophagy

Richard A. Flavell, Yale University School of Medicine, USA
Inflammasome Sensing and Metabolic Disease

Martin J. Blaser, New York University School of Medicine, USA
Antibiotics and the Microbiome

Christopher B. Newgard, Duke University Medical Center, USA
Intermediary Metabolism and Insulin Resistance

Murielle M. Veniant, Amgen Inc., USA
New Therapeutics in Type 2 Diabetes

Feifan Guo, Institutes for Nutritional Sciences, Sibs, CAS, China
Branched Chain Amino Acids and Metabolic Signaling

Wataru Ogawa, Kobe University, Japan
Novel Variants of PGC1alpha and Muscle Energy Efficiency

Struan F. A. Grant, Children’s Hospital of Philadelphia Research Institute, USA
Genetics of Common Pediatric Obesity

Cristen J. Willer, University of Michigan, USA
Genetic Architecture of Obesity

I. Sadaf Farooqi, University of Cambridge, UK
Genetic Basis of Severe Obesity

Abhimanyu Garg, University of Texas Southwestern Medical Center, USA
Genetic Basis of Lipodystrophies

Alan R. Tall, Columbia University, USA
Insulin Control of Hepatic Lipoprotein Turnover

William C. Sessa, Yale University School of Medicine, USA
Insulin Signaling in the Vasculature

Rudolf Zechner, University of Graz, Austria
Lipolysis and Energy Metabolism

Scott Sternson, HHMI/Janelia Farm Research Campus, USA
Neural Circuits Regulating Feeding and Hunger

Roger D. Cone, Vanderbilt University, USA
Development of Allosteric Modulators of the MC4R for the Treatment of Melanocortin Obesity Syndrome

Michael Rosenbaum, Columbia University Medical College, USA
Leptin Replacement Therapy

Derek Leroith, Mt.Sinai School of Medicine, USA
Diabetes and Cancer: The Role of Insulin and IGFs

Timothy E. McGraw, Weill Medical College of Cornell University, USA
Cancer Metabolism

Kathryn E. Wellen, University of Pennsylvania, USA
Role of Posttranslational Modifications in Linking Metabolism and Gene Expression

Hans-Ulrich Häring, Eberhard-Karls University Tübingen, Germany
Insulin Resistance, Fatty Liver and Liver Cancer

Joseph T. Bass, Northwestern University, USA
Circadian Regulation of Metabolic Function

Satchidananda Panda, The Salk Institute for Biological Studies, USA
Rhythmic Control of Feeding and Metabolism

Joseph S. Takahashi, HHMI/University of Texas Southwestern Medical Center, USA
Molecular Mechanisms of the Mammalian Circadian Clock

Susumu Seino, Kobe University Graduate School of Medicine, Japan
Molecular Signaling and Insulin Secretion

Domenico Accili, Columbia University, USA
Beta-Cell Dedifferentiation

Andrew F. Stewart, Mount Sinai School of Medicine, USA
Beta Cell Expansion Strategies

Steven A. Kliewer, University of Texas Southwestern Medical Center, USA
FGF21: From Feast to Famine to Pharmacology

Ruth E. Gimeno, Eli Lilly & Company, USA
Secreted Proteins as Targets for Metabolic Disorders

12 Jan - 17 Jan 2014
meeting website