Quality Control – From Molecules to Organelles

Research on quality control and stress response systems at the DNA, RNA and protein levels is experiencing explosive growth due to the realization of its importance in cell biology, ageing and major diseases.

Cells constantly suffer damage and make errors. This is the consequence of the intrinsic biochemical fragility of molecules and the limited robustness and precision of cellular processes. A multitude of internal and environmental stress insults aggravates this situation. All cells from bacteria to human have developed powerful quality control systems. These detect and minimize the damage that would ensue if mistakes and abnormal molecules went unchecked and uncorrected:

•Safeguarding systems which ensure proper performance of cellular processes or establish homeostatic environments, thereby avoiding errors and damage from occurring.
•Damage repair systems which detect damaged or abnormal macromolecules and repair or eliminate these.
•Stress response pathways that increase the cell's capacity to cope with specific or global stress.

This symposium addresses the molecular mechanisms of these systems, generating a unique forum of interdisciplinary discussion on quality control mechanisms of the genome (DNA), the transcriptome (RNA) and the proteome, and thus bringing together experts from traditionally separated fields.

+ show speakers and program
Elisa Izaurralde, Max Planck Institute for Developmental Biology, Germany

Stefan Jentsch, Max Planck Institute of Biochemistry, Germany

Jonathan Weissman, University of California, USA

Andrés Aguilera, Andalusian Molecular Biology and Regenerative Medicine Centre, Spain

Angelika B. Amon, Koch Institute for Integrative Cancer Research, HHMI, MIT, USA

Paul Anderson, Harvard University, USA

Cecília M. Arraiano, University of Lisbon, Portugal

Anne Bertolotti, MRC Laboratory of Molecular Biology, United Kingdom

Tony Carr, CanceGenome Damage and Stability Centre, University of Sussex, United Kingdom

Don W. Cleveland, Ludwig Institute for Cancer Research, USA

Elena Conti, Max Planck Institute of Biochemistry, Germany

Patrick Cramer, University of Munich, Germany

Ivan Dikic, Goethe University, Frankfurt, Germany

Andy Dillin, Salk Institute, USA

Judith Frydman, Stanford University, USA

Rachel Green, Johns Hopkins University School of Medicine, USA

Ulrich Hartl, Max-Planck-Institut of Biochemistry, Germany

Andreas Kulozik, University of Heidelberg, Germany

Jennifer Lippincott-Schwartz, NICHD, USA

Rick Morimoto, Northwestern University, USA

Andrea Musacchio, Max-Planck Institute of Molecular Physiology, Germany

Kaz Nagata, Kyoto Sangyo University, Japan

Michael Rape, University of California, USA

Lea Sistonen, Åbo Akademi University, Finland

Thomas Sommer, MDC Berlin, Germany

Jesper Svejstrup, Cancer Research UK, United Kingdom

19 Sep - 22 Sep 2012
meeting website