Much of the mammalian genome is transcribed into long non-coding RNAs, but their biological roles -- such as transcriptional regulation via recruitment of histone-modifying enzymes – are only beginning to be discovered. At the same time, bacterial non-coding RNAs are being found to function as small-molecule-sensing riboswitches and as elements of the CRISPR defense system. For all of these biological systems, a key remaining problem is to understand the detailed mechanism of action. Listing and comparing all of the long ncRNAs, riboswitches, and CRISPR elements genome-wide and among species is useful, but how does the RNA function in each of these systems? The goal of this Keystone Symposium is to stimulate conversations between scientists who work on these very diverse RNA systems, so they can share conceptual frameworks and experimental techniques. This goal will be accomplished by convening an exceptional group of academic and industrial scientists and students to share their insights.
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THURSDAY, FEBRUARY 27
16:00—20:00 Arrival and Registration
FRIDAY, FEBRUARY 28
07:00—08:00 Breakfast
08:00—09:00 Keynote Address
Registered attendees can view abstracts starting on 01/27/2014
Phillip A. Sharp, Massachusetts Institute of Technology, USA
09:00—11:15 Epigenetics and ncRNAs
Registered attendees can view abstracts starting on 01/27/2014
Anton Wutz, University of Cambridge, UK
Developmental Regulation of Noncoding RNA Function of the Mouse X Inactivation Center
Jeannie T. Lee, Massachusetts General Hospital, USA
XIST and TSIX in X-Chromosome Inactivation
Denise P. Barlow, Center for Molecular Medicine, Austria
Gene Silencing by Macro LncRNA Transcriptional Interference
Short Talk(s) Chosen from Abstracts
09:40—10:00 Coffee Break
11:15—13:00 Poster Setup
13:00—22:00 Poster Viewing
On Own for Lunch and Recreation
16:30—17:00 Coffee Available
17:00—19:00 ncRNAs and Transcriptional Control
Registered attendees can view abstracts starting on 01/27/2014
Danny F. Reinberg, HHMI/New York University, USA
Histone Modification and Long ncRNAs
Ingrid Grummt, German Cancer Research Center, Germany
rRNA Regulation by ncRNAs
Edith Heard, Institut Curie, France
A New lncRNA
Short Talk Chosen from Abstracts
19:00—20:00 Social Hour w/ Lite Bites
19:30—22:00 Poster Session 1
SATURDAY, MARCH 1
07:00—08:00 Breakfast
08:00—11:00 Bacterial ncRNAs
Registered attendees can view abstracts starting on 01/27/2014
Ronald R. Breaker, Yale University, USA
Large ncRNAs in Bacteria
Gisela T. Storz, NICHD, National Institutes of Health, USA
Bacterial Riboregulators
Pascale Cossart, Institut Pasteur, France
ncRNAs and Bacterial Pathogens, e.g. Listeria
Karen M. Wassarman, University of Wisconsin-Madison, USA
6S RNA
Short Talk(s) Chosen from Abstracts
09:20—09:40 Coffee Break
11:00—13:00 Poster Setup
13:00—22:00 Poster Viewing
On Own for Lunch and Recreation
14:30—16:30 Workshop 1
Short Talks Chosen from Abstracts
16:30—17:00 Coffee Available
17:00—19:00 Riboswitches and CRISPR
Registered attendees can view abstracts starting on 01/27/2014
Jennifer A. Doudna, HHMI/University of California, Berkeley, USA
CRISPRs: Mechanism and Structure
Beatrix Suess, Technical University Darmstadt, Germany
Engineered Riboswitches
Robert T. Batey, University of Colorado, Boulder, USA
Structure and Mechanism of Bacterial Riboswitches
Short Talk Chosen from Abstracts
19:00—20:00 Social Hour w/ Lite Bites
19:30—22:00 Poster Session 2
SUNDAY, MARCH 2
07:00—08:00 Breakfast
08:00—11:00 RNA Methods, Diagnostics and Therapeutics
Registered attendees can view abstracts starting on 01/27/2014
Howard Y. Chang, Stanford University, USA
High-Throughput Analysis of ncRNA Structure and Function
Larry Gold, Somalogic Inc., USA
Nucleic Acid SOMAmers for Diagnostics and Therapeutics
Bruce A. Sullenger, Duke University, USA
Clinical Applications of Antithrombotic Non-Coding RNAs
Arthur M. Krieg, RaNa Therapeutics, USA
Selectively Activating Gene Expression by Targeting PRC2-Associated lncRNAs
Short Talk(s) Chosen from Abstracts
09:20—09:40 Coffee Break
11:00—13:00 Poster Setup
13:00—22:00 Poster Viewing
On Own for Lunch and Recreation
16:30—17:00 Coffee Available
17:00—19:00 Catalytic RNAs and RNPs
Registered attendees can view abstracts starting on 01/27/2014
Anna Marie Pyle, Yale University, USA
The Tertiary Structures of Long Noncoding RNAs: Lessons from Catalytic Introns
Peter Baumann, Stowers Institute for Medical Research, USA
Telomerase Biogenesis and Regulation
Joachim Lingner, École Polytechnique Fédérale de Lausanne (EPFL), Switzerland
Telomere Functions of TERRA ncRNA
Short Talk Chosen from Abstracts
19:00—20:00 Social Hour w/ Lite Bites
19:30—22:00 Poster Session 3
MONDAY, MARCH 3
07:00—08:00 Breakfast
08:00—11:00 Genome-Wide Analysis
Registered attendees can view abstracts starting on 01/27/2014
John L. Rinn, Harvard University, USA
Linking RNA to Cellular Differentiation
Jonathan S. Weissman, University of California, San Francisco, USA
What's on Ribosomes?
Thomas R. Gingeras, Cold Spring Harbor Laboratory, USA
Lessons Learned from Complex Genomes
Caroline Dean, John Innes Centre, UK
Linking Antisense RNA and Chromatin in Flowering Control
Short Talk(s) Chosen from Abstracts
09:20—09:40 Coffee Break
On Own for Lunch and Recreation
14:30—16:30 Workshop 2
Short Talks Chosen from Abstracts
16:30—17:00 Coffee Available
17:00—19:00 Long ncRNAs and Chromatin
Registered attendees can view abstracts starting on 01/27/2014
Speaker to be Announced
Geneviève Almouzni, Centre National de la Recherche Scientifique, France
Satellite Transcripts and Heterochromatin Formation during Development and in Cancer
Thomas R. Cech, HHMI/University of Colorado, USA
FUS/TLS, ncRNAs and RNA Pol II
Short Talk Chosen from Abstracts
19:00—20:00 Social Hour w/ Lite Bites
20:00—23:00 Entertainment
TUESDAY, MARCH 4
Departure
