The recent discovery of mutations affecting metabolic enzymes such as succinate dehydrogenase, fumarate hydratase, and isocitrate dehydrogenase provides genetic evidence that altered cellular metabolism can cause cancer. Moreover, it has become apparent that a number of proteins that regulate processes pertinent to cellular transformation, such as enzymes that affect chromatin structure, respond to specific cellular metabolites. Finally, technologies for monitoring cellular metabolism are improving rapidly including technologies that lend themselves to non-invasive imaging. The goals of this meeting are to bring together a diverse group of scientists from academia and industry with basic and translational interests surrounding cancer metabolism. A particular focus will be on metabolic enzymes as potential targets for treating and/or imaging cancer cells. Toward this end this meeting hopes to attract a diverse group of scientists including biologists, chemists, and engineers. This meeting should provide participants with a greater understanding of the language and logic of cellular metabolism and provide a sense of the translational opportunities emerging from our growing knowledge of the role that altered metabolism plays in cancer.
+ show speakers and program
SUNDAY, MARCH 16
16:00—20:00 Arrival and Registration
MONDAY, MARCH 17
07:00—08:00 Breakfast
08:00—09:30 Keynote Session (Joint)
Registered attendees can view abstracts starting on 02/16/2014
M. Celeste Simon, HHMI/University of Pennsylvania, USA
Oxygen, Lipids and Cancer Cell Metabolism
Steven L. McKnight, University of Texas Southwestern Medical Center, USA
Acetyl-CoA as a Central Node in Cancer Metabolism
09:30—09:50 Coffee Break
09:50—12:00 Novel Metabolic Pathways in Cancer (Joint)
Registered attendees can view abstracts starting on 02/16/2014
Matthew G. Vander Heiden, Massachusetts Institute of Technology, USA
Glutamine and Serine Metabolism
David M. Sabatini, Whitehead Institute for Biomedical Research, USA
Amino Acids, Sugars and Cancer Metabolism
Karen H. Vousden, Beatson Institute for Cancer Research, UK
p53 and Metabolism
Ralph J. DeBerardinis, University of Texas Southwestern Medical Center, USA
Metabolic Versatility in Cancer Cells
11:15—13:00 Poster Setup
13:00—22:00 Poster Viewing
On Own for Lunch and Recreation
14:30—16:30 Workshop: Monitoring Metabolism
Hilary A. Coller, Princeton University, USA
Metabolism of Quiescent Cells
Hank F. Kung, University of Pennsylvania, USA
Novel PET Probes Based on Altered Tumor Metabolism
Linda C. Hsieh-Wilson, California Institute of Technology, USA
The Interplay of Protein Glycosylation and Cancer Metabolism
Alan Saghatelian, Harvard University, USA
Protein-Metabolite Interactions
16:30—17:00 Coffee Available
17:00—19:00 Succinate Dehydrogenase and Fumarate Hydratase
Registered attendees can view abstracts starting on 02/16/2014
Patrick J. Pollard, University of Oxford, UK
Pathogenesis of Fumarate Hydratase Mutations
Eyal Gottlieb, Beatson Institute for Cancer Research, UK
Targeting FH Mutant Tumors
Navdeep S. Chandel, Northwestern University, USA
Krebs Cycle Mutations and Cancer
Short Talk Chosen from Abstracts
Following Session is for Metabolism and Angiogenesis (X5)
17:00—19:00 Metabolism and Vascular Branching I
Registered attendees can view abstracts starting on 02/16/2014
Speaker to be Announced
Massimo Santoro, University of Torino, Italy
Novel Non-Mitochondrial Redox Regulator in Endothelial Cells
Kari K. Alitalo, University of Helsinki, Finland
Metabolic Effects of VEGF-B
Short Talk Chosen from Abstracts
19:00—20:00 Social Hour w/ Lite Bites
19:30—22:00 Poster Session 1
TUESDAY, MARCH 18
07:00—08:00 Breakfast
08:00—11:00 Isocitrate Dehydrogenase
Registered attendees can view abstracts starting on 02/16/2014
William G. Kaelin, Jr., Dana Farber Cancer Institute, USA
Transformation by Mutant IDH
Craig B. Thompson, Memorial Sloan-Kettering Cancer Center, USA
Epigenetic Control by Mutant IDH
Elizabeth Maher, University of Texas Southwestern Medical Center, USA
Metabolic Imaging of IDH Mutant Brain Tumors
Katharine E. Yen, Agios Pharmaceuticals, USA
Targeting Mutant IDH
Short Talk(s) Chosen from Abstracts
Following Session is for Metabolism and Angiogenesis (X5)
08:00—11:00 Metabolism and Vascular Branching II
Registered attendees can view abstracts starting on 02/16/2014
Michael Potente, Max-Planck-Institute for Heart and Lung Research, Germany
Linking Angiogenesis and Metabolism through FOXO Transcription Factors
Peter F. Carmeliet, University of Leuven, VIB, Belgium
Targeting Glycolysis in Vascular Branching
Christer Betsholtz, Karolinska Institutet, Sweden
Lipid Signals in Vascular Quiescence
M. Luisa Iruela-Arispe, University of California, Los Angeles, USA
Endothelial VEGFR2 Signaling in Diabetes
Short Talk(s) Chosen from Abstracts
09:20—09:40 Coffee Break
11:00—13:00 Poster Setup
13:00—22:00 Poster Viewing
On Own for Lunch and Recreation
16:30—17:00 Coffee Available
17:00—19:00 Lactate and Monocarboxylate Transporters
Registered attendees can view abstracts starting on 02/16/2014
Michael P. Lisanti, University of Manchester, UK
Changing the Cancer Paradigm: New Strategies for Personalized Medicine and Drug Discovery
Jacques Pouysségur, University of Nice, France
Hypoxic-Regulation of MCT Transporters
John Kurhanewicz, University of California, San Francisco, USA
Using I\in Vivo Hyperpoalrized 13C MR Imaging for Measuring Metabolic Fluxes Important to Cancer Progression and Therapeutic Response
Short Talk Chosen from Abstracts
Following Session is for Metabolism and Angiogenesis (X5)
17:00—19:00 Novel Metabolic Pathways in Cancer II
Registered attendees can view abstracts starting on 02/16/2014
James M. Phang, NCI at Frederick, CCR, NIH, USA
The Proline Metabolic Axis and Cancer
Yury I. Miller, University of California, San Diego, USA
Cholesterol Efflux and Angiogenesis
Holger Gerhardt†, London Research Institute, UK
Talk Title to be Determined
Short Talk Chosen from Abstracts
19:00—20:00 Social Hour w/ Lite Bites
19:30—22:00 Poster Session 2
WEDNESDAY, MARCH 19
07:00—08:00 Breakfast
08:00—11:00 Metabolism and Epigenetic Enzymes
Registered attendees can view abstracts starting on 02/16/2014
Anjana Rao, La Jolla Institute for Allergy and Immunology, USA
Talk Title to be Determined
Leonard P. Guarente, Massachusetts Institute of Technology, USA
SIRTs in Cancer and Aging
Chuan He, University of Chicago, USA
Epigenetic DNA and RNA Demethylation in Mammalian Regulation
Anne Brunet, Stanford University, USA
Metabolic and Epigenetic Regulation of Aging
Short Talk(s) Chosen from Abstracts
Following Session is for Metabolism and Angiogenesis (X5)
08:00—11:00 Metabolism and Anti-Angiogenic Therapy
Registered attendees can view abstracts starting on 02/16/2014
Rakesh K. Jain, Massachusetts General Hospital, USA
Alleviating Tumor Hypoxia for Cancer Treatment
Patrizia Agostinis, KU Leuven, Belgium
Vessel Normalization by the Autophagy Blocker Chloroquine
Olivier Feron, UCLouvain, Belgium
Targeting Lactate in Angiogenesis
Adrian L. Harris, University of Oxford, Weatherall Institute of Molecular Medicine, UK
Metabolic Response to Anti-Angiogenic Therapy
Short Talk(s) Chosen from Abstracts
09:20—09:40 Coffee Break
11:00—13:00 Poster Setup
13:00—22:00 Poster Viewing
On Own for Lunch and Recreation
16:30—17:00 Coffee Available
17:00—19:00 Lipid Metabolism
Registered attendees can view abstracts starting on 02/16/2014
Daniel K. Nomura, University of California, Berkeley, USA
Mapping Dyregulated Metabolic Pathways in Cancer Using Functional Proteomic and Metabolomic Platforms
Gerald Hoefler, Medical University of Graz, Austria
Lipid Metabolism and Cancer Cachexia
Ernst R. Lengyel, University Of Chicago, USA
Crosstalk between Cancer Cells and Adipocytes
Short Talk Chosen from Abstracts
Following Session is for Metabolism and Angiogenesis (X5)
17:00—19:00 Metabolism and Pathological Angiogenesis
Registered attendees can view abstracts starting on 02/16/2014
Yoshiaki Kubota, Keio University, Japan
Oxidative Stress as a Target for Anti-Angiogenic Therapy
Michael Simons, Yale University, USA
Vascular Fate Determination and Metabolism
Massimiliano Mazzone, KU Leuven, Belgium
Influence of Macrophage Metabolism on Vessel Shape: Implications for Cancer
Short Talk Chosen from Abstracts
19:00—20:00 Social Hour w/ Lite Bites
19:30—22:00 Poster Session 3
THURSDAY, MARCH 20
07:00—08:00 Breakfast
08:00—11:00 Novel Cancer Metabolic Targets (Joint)
Registered attendees can view abstracts starting on 02/16/2014
Almut Schulze, Cancer Research UK, UK
Phosphofructokinase
Jonathan Hurov, Agios Pharmaceuticals, USA
Targeting Cancer Metabolism
Douglas R. Green, St. Jude Children's Research Hospital, USA
Sphingolipid Metabolism
Peter K. Jackson, Stanford University, USA
Targeting Glycolysis
Short Talk(s) Chosen from Abstracts
09:20—09:40 Coffee Break
On Own for Lunch and Recreation
16:30—17:00 Coffee Available
17:00—19:00 Novel Cancer Metabolic Targets II
Registered attendees can view abstracts starting on 02/16/2014
Benjamin F. Cravatt III, The Scripps Research Institute, USA
Targeting Lipid Metabolism
Sandaruwan Geeganage, Eli Lilly and Company, USA
NAMPT Inhibitors and Cancer
Nissim Hay, University of Illinois at Chicago, USA
Targeting Glucose Metabolism for Cancer Therapy
Short Talk Chosen from Abstracts
Following Session is for Metabolism and Angiogenesis (X5)
17:00—19:00 Metabolism and Angiogenesis: Therapeutic Implications
Registered attendees can view abstracts starting on 02/16/2014
George D. Yancopoulos, Regeneron Pharmaceuticals, Inc., USA
Targeting VEGF and VEGF-Trap
Napoleone Ferrara, University of California, San Diego, USA
Targeting VEGF for Therapy of Cancer and Intraocular Neovascular Disorders
Douglas Hanahan, ISREC, Switzerland
Targeting Angiogenesis in Cancer
Short Talk Chosen from Abstracts
19:00—20:00 Social Hour w/ Lite Bites
20:00—23:00 Entertainment
FRIDAY, MARCH 21
Departure
