Glyoxalase Centennial : 100 Years of Glyoxalase Research and Emergence of Dicarbonyl Stress

This year is the centenary of the Glyoxalase System. It provides protection against damaging modification of proteins and nucleotides by methylglyoxal. Methylglyoxal accumulation - “dicarbonyl stress” – may provide the basis for improved understanding of mechanisms of disease and health decline in ageing, and suggest new strategies for therapeutics and functional food development. Please join us.


History of glyoxalase
Experimental methods
Dicarbonyl stress
Reproductive disorders
Diet and health
Diabetes and diabetic complications
Cardiovascular disease
Renal failure
Psychiatric and neurological disorders
Cancer and multidrug resistance
Protozoan and bacterial metabolism
Plant stress tolerance
+ show speakers and program
Main conference
Methylglyoxal-Mediated Anxiolysis – Something to Rack One’s Brain
Boris Hambsch (University of Bonn, Germany)
Dicarbonyl stress and glyoxalases in ovarian function
Carla Tatone (University of L'Aquila, Italy)
Casper Schalkwijk (Cardiovascular Research Institute Maastricht (CARIM), The Netherlands)
Bacterial glyoxalase I enzymes: structural and biochemical investigations
John Honek (University of Waterloo, Canada)
Carbonyl stress as novel concept of pathophysiology of schizophrenia
Masanori Itokawa (Tokyo Metropolitan University, Japan)
Main conference
Naila Rabbani (University of Warwick, United Kingdom)
Paul Beisswenger (Dartmouth Medical School, U.S.A.)
Main conference
Paul Thornalley (University of Warwick, United Kingdom)
Reactive metabolites and late diabetic complications
Peter Nawroth (University of Heidelberg, Germany)
Glycative stress and glyoxalase in kidney disease and aging
Reiko Inagi (University of Tokyo, Japan)
Sneh L Singla-Pareek (ICGEB, New Delhi, India)
Susan Wyllie (University of Dundee, United Kingdom)
Methods Workshop
Measurement of Glo1 CNV
Alaa Shafie (University of Warwick, United Kingdom)
Measurement of glyoxlase activities
Makoto Arai (Tokyo Metropolitan University, Japan)
Measurement of glyoxalase expression
Mingzhan Xue (University of Warwick, United Kingdom)
Naila Rabbani (University of Warwick, United Kingdom)
Paul Thornalley (University of Warwick, United Kingdom)

27 Nov - 29 Nov 2013
United Kingdom
meeting website