Coenzyme A and its Derivatives in Cellular Metabolism and Disease

Join us in London in March 2014 for an exciting, topical and long-overdue conference on “Coenzyme A and its derivatives in cellular metabolism and disease”. CoA is an indispensable cofactor in all living organisms and the Nobel Prize was awarded to Fritz Lipmann in 1953 for its discovery. CoA and its thioesters (Acetyl-CoA, Malonyl-CoA, Acyl-CoA, HMG-CoA and others) are essential for a diverse range of metabolic pathways, the regulation of gene expression, growth and proliferation.

Dysregulation of CoA biosynthesis or CoA thioester homeostasis is linked to various human pathologies. Therefore the CoA biosynthetic pathway is an attractive target for drug discovery. The purpose of this focused meeting is to bring together researchers worldwide to discuss the most recent advances on the role of CoA and its thioesters in health and diseases. We have assembled a program that includes leading international researches in the field.

Metabolic functions of CoA and its thioesters
The role of CoA and CoA derivatives in the regulation of cell growth and proliferation
Deregulation of CoA biosynthesis and disruption of homeostasis in human pathologies
Targeting the CoA biosynthetic pathway for drug discovery
Oral communication slots are available at this meeting. All attendees, particularly researchers in the early stages of their career, are invited to submit a poster abstract for consideration as an oral communication. We aim to select 8-10 oral communications (20 min each). In addition, a one hour slot will be allocated for flash poster presentations (5 min each) which can provide an excellent opportunity for young researchers and group leaders to outline their research and future directions.
+ show speakers and program
Thursday 20 March 2014

Acetyl-CoA and the regulation of cell growth and proliferation
Benjamin Tu (UT Southwestern Medical Center, Dallas, U.S.A.)

Targeting the Coenzyme A biosynthetic enzymes for antimicrobial drug development
Erick Strauss (Stellenbosch University, South Africa)

Coenzyme A and its derivatives in cellular metabolism and disease
Gary Lopaschuk (University of Alberta, Canada)

Regulation of the cell cycle by Coenzyme A
Ivan Gout (University College London, United Kingdom)

Human pantetheinases in health and disease
Joost Schalkwijk (University Medical Centre Nijmegen, The Netherlands)

The coenzyme A biosynthesis pathway of the human malaria parasite and its potential as a drug target
Kevin Saliba (The Australian National University, Australia)

Manipulating Coenzyme A metabolism to prevent neurodegeneration
Ody Sibon (University of Groningen, Netherlands)

How defects in pantothenate metabolism cause neurodegeneration
Susan Hayflick (Oregon Health & Science University, U.S.A.)

Physiological roles of the Pantothenate kinases
Suzanne Jackowski (St. Jude Children‘s Research Hospital, U.S.A.)

Alteration of Coenzyme A biosynthetic pathway in Neurodegeneration with Brain Iron Association syndromes
Valeria Tiranti (IRCCS Foundation Neurological Institute , Italy)

20 Mar - 21 Mar 2014
United Kingdom
meeting website