Mechanisms of Epilepsy & Neuronal Synchronization

The 2012 Gordon Conference on Mechanisms of Epilepsy and Neuronal Synchronization will present cutting edge research on the theme of functional reorganization in the epileptic brain. The issues will be addressed at multiple levels, from cellular and molecular to circuits and networks. The focus will be on three important and persistent questions in the epilepsy field. What are the mechanisms underlying acute seizures? What progressive changes in brain organization and function lead to the chronic condition of epilepsy? What are the relationships between the mechanisms of epilepsy and the co-morbidities that are frequently encountered in this disorder? These questions will be considered specifically in sessions devoted to epileptogenesis, seizure generation, and developmental epilepsies and their co-morbidities. The issues raised during these sessions, including the reorganization of neural circuits in epilepsy, will be further developed in sessions that focus on exciting new methods of circuit analysis and their application in epilepsy research; mechanisms associated with reorganization of interneurons and alterations in chloride homeostasis; and the reorganization of several ion channels that could suggest targets for therapy. The purpose of the Conference is to bring together specialists from multiple disciplines to discuss the complex issues that arise in the processes of seizure generation and progression. It is expected that the exchange of new ideas will influence the critical next stage of experimental epilepsy research.

The collegial atmosphere of the Conference, with programmed discussion sessions as well as opportunities for informal gatherings in the afternoons and evenings, will provide opportunities for scientists to brainstorm and promote increased interactions among investigators in diverse areas of basic epilepsy research. The Conference will provide opportunities for junior scientists and graduate students to present their work in poster format and exchange ideas with leaders in the field. In addition to presentations by invited speakers, 8 short talks will be selected from submitted abstracts one to two weeks prior to the start of the meeting.

+ show speakers and program
Challenges for Epilepsy Research
(David Prince / Daniel Lowenstein / Istvan Mody)
Epileptogenesis: Can We Prevent It?
(Douglas Coulter / Asla Pitkänen / Tallie Baram / James McNamara / Pico Caroni)
Seizure Generation: Where do Seizures Begin and How Do They Spread?
(Christophe Bernard / Brian Litt / Gilles Huberfeld / Sydney Cash)
Circuit Analysis in Epilepsy with Optogenetics: Lighting Up a Darkened Brain
(Helen Scharfman / Karl Deisseroth / Ivan Soltesz / John Huguenard / Jin Lee)
Network Dynamics in Epilepsy: Novel Approaches for Dissecting the Networks
(John Hablitz / Baljit Khakh / Edward Callaway / Andrew Trevelyan)
Interneuron Reorganization in Epilepsy: How Many Changes Can We Find?
(Monique Esclapez / Gord Fishell / Dimitri Kullmann / Chris McBain / Paul Buckmaster)
Multiple Ways of Altering Excitability in Epilepsy: What Can be Targeted?
(Manisha Patel / Kevin Staley / Gary Yellen / Dane Chetkovich)
Developmental Epilepsies and Co-Morbidities: Are There Common Mechanisms?
(John Swann / Amy Brooks-Kayal / Peter Crino / Massimo Mantegazza / Farah Lubin)
Channel Reorganization in the Epileptic Brain: Do the Genetics Suggest Targets?
(Jaideep Kapur / Samuel Berkovic / Robert Macdonald / Jeffrey Noebels)

19 Aug - 24 Aug 2012
Waterville Valley
United States of America
meeting website