Many oncogenes and tumour suppressor genes have been identified and mapped to signaling pathways that regulate cell growth and death. Dysregulation allows oncogenes and tumour suppressor genes to transform mammalian cells and cancers arise in conditions where multiple such events occur in the same cell. It has also been found that a subset of the cells present in a tumour, called cancer stem cells, retain the ability to self-renew and to give rise to all cell types in a particular cancer.
An emerging concept is that tumours also strongly depend on external signals for maintenance and expansion. To fully understand tumour development and progression, a deeper knowledge of the cross-talk between tumour cells and their microenvironment and the interactions between cancer cells and cancer stem cells is needed.
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Speakers
Confirmed Speakers
Kari Alitalo
Kari Alitalo
University of Helsinki, Finland
Frances Balkwill
Barts Cancer Institute, United Kingdom
Mariano Barbacid
Spanish National Cancer Research Centre, Spain
Eduard Batlle
Eduard Batlle
Institute for Research in Biomedicine (IRB), Spain
Joanne Brugge
Harvard Medical School, USA
Vincenzo Cerundolo
Vincenzo Cerundolo
University of Oxford, United Kingdom
Mike Clarke
Stanford University, USA
Maria Pia Cosma
CRG Barcelona, Spain
Bruce Edgar
Bruce Edgar
German Research Center (DKFZ), Gremany
Mikala Egeblad
Cold Spring Harbor Laboratory, USA
Rudolf Grosschedl
Rudi Grosschedl
Max Planck Institute of Immunobiology and Epigenetics, Germany
Lisa Johnson
BC Cancer Agency, Canada
Jos Jonkers
Netherlands Cancer Institute, The Netherlands
Chris Marshall
The Institute of Cancer Research, United Kingdom
Jan Paul Medema
Jan Paul Medema
Academic Medical Center, The Netherlands
Luis Parada
UT Southwestern, USA
Emmanuelle Passegué
Emmanuelle Passegué
UCSF, USA
Catrin Pritchard
Catrin Pritchard
University of Leister, United Kingdom
Andreas Trumpp
German Cancer Research Centre (DKFZ), Germany
Terry van Dyke
National Cancer Institute, USA
Karen Vousden
The Beatson Institute for Cancer Research, United Kingdom
Zena Werb
University of San Francisco, USA
