Tumour Microenvironment and Signalling

Many oncogenes and tumour suppressor genes have been identified and mapped to signaling pathways that regulate cell growth and death. Dysregulation allows oncogenes and tumour suppressor genes to transform mammalian cells and cancers arise in conditions where multiple such events occur in the same cell. It has also been found that a subset of the cells present in a tumour, called cancer stem cells, retain the ability to self-renew and to give rise to all cell types in a particular cancer.

An emerging concept is that tumours also strongly depend on external signals for maintenance and expansion. To fully understand tumour development and progression, a deeper knowledge of the cross-talk between tumour cells and their microenvironment and the interactions between cancer cells and cancer stem cells is needed.

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Confirmed Speakers

Kari Alitalo
Kari Alitalo
University of Helsinki, Finland

Frances Balkwill
Barts Cancer Institute, United Kingdom

Mariano Barbacid
Spanish National Cancer Research Centre, Spain

Eduard Batlle
Eduard Batlle
Institute for Research in Biomedicine (IRB), Spain

Joanne Brugge
Harvard Medical School, USA

Vincenzo Cerundolo
Vincenzo Cerundolo
University of Oxford, United Kingdom

Mike Clarke
Stanford University, USA

Maria Pia Cosma
CRG Barcelona, Spain

Bruce Edgar
Bruce Edgar
German Research Center (DKFZ), Gremany

Mikala Egeblad
Cold Spring Harbor Laboratory, USA

Rudolf Grosschedl
Rudi Grosschedl
Max Planck Institute of Immunobiology and Epigenetics, Germany

Lisa Johnson
BC Cancer Agency, Canada

Jos Jonkers
Netherlands Cancer Institute, The Netherlands

Chris Marshall
The Institute of Cancer Research, United Kingdom

Jan Paul Medema
Jan Paul Medema
Academic Medical Center, The Netherlands

Luis Parada
UT Southwestern, USA

Emmanuelle Passegué
Emmanuelle Passegué

Catrin Pritchard
Catrin Pritchard
University of Leister, United Kingdom

Andreas Trumpp
German Cancer Research Centre (DKFZ), Germany

Terry van Dyke
National Cancer Institute, USA

Karen Vousden
The Beatson Institute for Cancer Research, United Kingdom

Zena Werb
University of San Francisco, USA

7 May - 10 May 2014
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