Lipids as molecular switches

Course summary: The course will focus on the involvement of individual lipid species as molecular switches in biologically important processes such as lipid sensing, membrane traffic, amyloid formation, and lipid–protein interactions. Leading lipid researchers will meet with young researchers to discuss basic and emerging topics. In addition, the lipid field is technically complex and recent technological advances will be addressed. Social interactions are an important aspect of the meeting.

We are pleased to present lectures will cover the following topics:

Lipids as molecular switches in lipid sensing: How are specific lipids such as phosphatidic acid, and sphingomyelin ‘sensed’ and how do lipids affect the activity of lipid sensing proteins such as oxysterol-binding proteins and CERT in the sphingomyelin rheostat?
Lipids as molecular switches in amyloid formation: How can the formation of amyloid fibrils be triggered by the presence of specific lipid species in biological membranes? This rapidly emerging field appears highly relevant for lipid research.
Lipids as molecular switches in lipid-protein interactions: How are lipid-protein interactions investigated at the individual species level (phosphoinositides) and at the -omics scale and how do they affect membrane curvature?
Lipids as molecular switches in membrane traffic: How are lipid homeostasis, lipid classes and individual lipid species involved in membrane traffic? The impressive progress in this field will be discussed.
Each topic will be combined with an enabling technology. There is increasing awareness that lipid handling is an important but difficult issue. In contrast to proteins, lipids are more difficult to manipulate or visualized without affecting their biophysical properties. Recently developed technology, however, provides first glimpses on breakthroughs in this particular technology area. Examples include GFP visualization, NMR of Lipid-protein complexes, STED (-FCS) microscopy, and high-end lipidomics by mass spectrometry. In this workshop we will discuss these novel lipid techniques in an integrative manner, i.e. coupled to a particular topic. The workshop will be organized in an informal setting to facilitate contacts and information exchange. Poster sessions, oral presentations and round table discussions are scheduled to stimulate interactions between the participants and the lecturers/tutors.
We are looking forward to an exciting workshop and to welcome you on the wonderful island of Spetses!
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Patricia Bassereau (Paris, France) (www)
Britta Brugger (Heidelberg, Germany) (www)
Christian Eggeling (Oxford, United Kingdom) (www)
Dorus Gadella (Amsterdam, Netherlands) (www)
Anne-Claude Gavin (EMBL, Germany) (www)
Bernd Helms (Utrecht, The Netherlands) (www)
Joost Holthuis (Osnabruck, Germany) (www)
Paavo Kinnunen (Aalto, Finland) (www)
Zoya Leonenko (Waterloo, Canada) (www)
Chris Loewen (Vancouver, Canada) (www)
Vivek Malhotra (Barcelona, Spain) (www)
Vesa Olkkonen (Helsinki, Finland) (www)
Howard Reizman (Geneva, Switzerland) (www)
Chuck Sanders (Nashville, USA) (www)
Harald Stenmark (Oslo, Norway) (www)
Felix Wieland (Heidelberg, Germany) (www)

25 Aug - 30 Aug 2014
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