V IMPPC Annual Conference and 4DCellFate Workshop

We are very pleased to welcome you to the mini web for our joint symposium: Integrative and Computational Biology.

One of the biggest opportunities in biology today is the ability to make precise, systematic measurements on a large scale and to computationally integrate large datasets to address fundamental questions in biology. We are now able to study how chromatin is organized in cells, how this organization changes during development, how chromatin and genomes are altered in cancer and how cancer genomes evolve. The big challenge that we now face is how to exploit all this data in meaningful ways and analyse it in order to transform it to basic knowledge and also to translate it to a better understanding of diseases. This knowledge will eventually lead to better diagnostics for diseases such as cancer, better predictions for prognosis and personalized treatments.

As a joint event between the Integrative Cancer Biology program of the Institute of Predictive and Personalized Medicine (IMPPC) and the FP7 Project 4DCellFate, coordinated by the CRG, this conference will be of interest to computational biologists as well as experimental researchers working in the fields of genomics, epigenetics and cancer. Leading scientists of international standing in the fields of computational and integrative biology will discuss cutting-edge developments in current topics ranging from chromatin biology, gene regulation and cancer genome evolution.

We very much hope you can join us at this very special event where data analysis and bench work will join hands, which we believe will provide some fascinating debates.
+ show speakers and program
Thursday 27 March
08.50 - 09.00
Welcome from the Organizers

Session 1: Big Biological Datasets

Ewan Birney

EMBL-EBI, Wellcome Trust Genome Campus, UK
EMBL-EBI and Elixir: A life science infrastructure
Olga Troyanskaya

Lewis-Sigler Institute for Integrative Genomics
A tissue-specific view of human disease from integrated data analysis
Roderic Guigo

Centre for Genomic Regulation, Spain
RNA Heterogeneity in the eurkaryotic cell
Short Talk to be selected from abstracts

10.50 - 11.20
Coffee and Poster Session

Session 2: Modelling Chromatin

Modesto Orozco

Institute for Research in Biomedicine (IRB Barcelona), University of Barcelona (UB) and Barcelona Supercomputing Center (BSC), Spain
Chromatin analyzed with the eyes of physics
Luca Giorgetti

Invited Short Talk Speaker
Institute Curie, France
Predictive polymer modeling reveals coupled fluctuations in chromosome conformation and transcription
Ana M. Rojas

Institute of Biomedicine of Seville (IBIS), Spain
Emergence and conservation of DNA Damage Response proteins affecting chromatin remodelling
12.30 - 13.30
Fast Track Session: Poster Presentations by Participants

Speed presentations by selected poster authors
Lunch and Poster Session

Lunch and Poster Session
Session 3: Cancer Genomics (Part I)

Alfonso Valencia

Spanish National Cancer Research Centre (CNIO), Spain
Analysis of Genomes and Cancer Genomes from an Evolutionary Perspective
Nuria Lopez-Bigas

ICREA and Pompeu Fabra University, Spain
Identification of cancer drivers across tumor types
Short Talk to be selected from abstracts

Coffee and Poster Session

Coffee and Poster Session
Session 4: Cancer Genomics (part II)

Niko Beerenwinkel

Swiss Federal Institute of Technology Zurich, Switzerland
Modeling cancer evolution from genomic data
Elizabeth Murchison

Wellcome Trust Sanger Institute, UK
Genetics and evolution of clonally transmissible cancers in dogs and Tasmanian devils

Center for Biological Sequence Analysis, Technical University of Denmark
Comorbidities and disease trajectories in cancer and beyond
Posters and Networking Session

Friday 28 March
09.30 - 10.00
Coffee and networking

10.00 - 11.50
Session 5: Regulatory Genomics


University of Cambridge
Environmental modulation of epigenetic states in the sperm methylome and their consequences
Tanya Vavouri

Institute of Predictive and Personalized Medicine of Cancer (IMPPC)
The influence of sequence composition on chromatin organization in the human genome
Mihaela Zavolan

Biozentrum, University of Basel, Switzerland
Decoding miRNA-based regulation with low and high-throughput data
Short Talk to be selected from Abstracts

Brunch and Poster Session

During this long break a selection of tapas will be provided and there will be another activity to be announced nearer the time
13.10 - 14.50
Session 6: Integrative Biology

Luis Serrano

Centre for Genomic Regulation (CRG), Spain
Protein competition as a means for cell specific signaling
Eileen Furlong

EMBL Heidelberg, Germany
cis-regulatory control during development
Nick Luscombe

University College London and Cancer Research UK London Research Institute (joint appointments)
Guardians of the transcriptome: how hnRNP C protects you from unwanted axons
Closing Remarks

27 Mar - 28 Mar 2014

meeting website