Mitochondrial Trafficking and Function in Neuronal Health and Disease

The regulated trafficking, morphology and function of mitochondria is essential for providing ATP at the correct spatial location to power neural computation. Mitochondria also sequester and buffer Ca2+, and play a key role in apoptotic signaling, so their positioning and function also affects regulation of Ca2+ dynamics and neuronal death. In neurons, the concentration of mitochondria in specific regions such as growth cones and synapses is important for correct neuronal function and development. Moreover mutations in proteins regulating mitochondrial dynamics compromise neuronal development and the formation, function and plasticity of synapses. Consequently, defective mitochondrial trafficking and function is increasingly implicated in neurological diseases. This meeting will focus on the latest insights into our understanding of the mechanisms that control mitochondrial trafficking, form and function in neurons. The latest approaches for imaging cellular bioenergetics and mitochondrial positioning will also be a focus. How altered mitochondrial dynamics contribute to neuronal dysfunction in neurological diseases including Alzheimer’s, Parkinson’s and Huntington’s diseases will also be a key focus.

+ show speakers and program

Mark Cookson (NIH, US)
"Roles of recessive Parkinson's disease genes in mitochondrial health and dysfunction"

Elizabeth Jonas (Yale University, US)
"Bcl-xL regulates neuronal metabolism and neurodegeneration by interacting with the ATP synthase"

Thomas Misgeld (Technical University Munich, Germany)
"In vivo imaging of mitochondrial dynamics in the vertebrate nervous system"

Vamsi Mootha (Broad Institute, US)
"From mitochondrial parts and pathways to pathogenesis"

Zheng Li (NIH, US)
"The canonical and non-canonical functions of mitochondria in neurons"

Leo Pallanck (University of Washington, US)
"Using drosophila to study the PINK1-Parkin mitochondrial quality control pathway"

Thomas Schwarz (Harvard, US)
"Regulation and misregulation of mitochondrial motility"

Luca Scorrano (Universite de Geneve, Switzerland)
"An autophagic filter prevents entry of mitochondria carrying mutated Opa1 in retinal ganglion cell neurites"

Zu-Hang Sheng (NIH, US)
"Axonal mitochondrial transport and its impact on synaptic transmission and mitochondrial quality control"

Stefan Strack (University of Iowa, US)
"Regulation of mitochondrial fission in neuronal development and plasticity"

Ella Bossy-Wetzel (University of Florida, US)
"Regulation of mitochondrial fission and fusion in health and disease"

Gary Yellen (Harvard University, US)
"Genetically-encoded fluorescent biosensors for metabolism"

25 Jun - 26 Jun 2012
United States of America
meeting website