Molecular Neurology and Therapeutics

This popular course alternates between Hinxton and Cold Spring Harbor and provides a concentrated examination of the molecular basis of neurological diseases and strategies in development for their treatment. Due to work to expand the Wellcome Trust Conference Centre at Hinxton, Molecular Neurology and Therapeutics 2012 will be held at Murray Edwards College, Cambridge.

The intensive, discussion-based programme offers a unique opportunity to learn the latest concepts and methodologies associated with the study of human neurological disorders such as Alzheimer's, Parkinson's, Amyotrophic Lateral Sclerosis, stroke, and ataxias. Participants will discuss in detail the strengths and weaknesses of the accumulated experimental evidence underlying our current understanding of these diseases. We will also discuss how we can apply this knowledge in developing therapeutic approaches for these diseases.

Many of these diseases can be approached by first understanding human genetics, and so the course will discuss both mendelian traits and more complex situations including recent examples of the application of genome-wide association studies (GWAS) to sporadic disease. The course will examine why many of these disorders share apparently common features of protein aggregation, specific vulnerability of certain classes of neuron, long incubation period and will discuss to what extent these features reflect common pathological mechanisms. The course will further explore how the underlying mechanisms may be targeted for potential diagnostic and therapeutic gain, applying lessons from genetic knowledge to inherited and sporadic diseases.

These fundamental questions will be discussed in the context of identifying the best experimental approaches to finding answers. These will include consideration of clinical and pathological data from human subjects through the use of experimental models including molecular approaches, cell biological and imaging studies, transgenic animal models including vertebrate and invertebrate models. Extended seminars and discussion by a wide range of leading investigators will further illuminate developments in the rapidly moving field. Participation in the course will provide an essential conceptual and methodological framework for anyone intending to pursue rigorous research.
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Course instructors
Mark Cookson National Institutes of Health, USA (LRRK2)
Beverly Davidson University of Iowa, USA (Lysosomal storage diseases)
Harry Orr University of Minnesota, USA (Ataxia)
Nicholas Wood University College London, UK (Genetic forms of Parkinson's disease)

Guest lecturers
Huw Morris University of Cardiff, UK (Clinical aspects of neurological diseases)
Karen Duff Columbia University, USA (Alzheimer’s disease)
Patrick Chinnery Newcastle University, UK (Mitochondrial diseases)
Bryan Traynor National Institutes of Health, USA (Amyotrophic Lateral Sclerosis and Frontotemporal Dementia)
Dave Nelson Baylor College of Medicine, USA (Fragile X and FXTAS)
Steve Warren Emory University, USA (Schizophrenia)
Costantino Iadecola Weill Cornell Medical College, USA (Stroke)
Dimitri Krainc Harvard Medical School, USA (Huntington's disease)
Su Metcalfe University of Cambridge, UK (Immunology and Multiple Sclerosis)

7 Jul - 14 Jul 2012
United Kingdom
meeting website