Metabolism, Diet and Disease

Metabolism, Diet and Disease
BioMed Central will hold its first conference on Metabolism, Diet and Disease in Washington DC from 29-31 May 2012.

The aim of the conference is to show how basic research on the biochemistry, cell biology and genetics of metabolism can address the major health problems of cancer, obesity, diabetes and insulin resistance, and explain ageing and longevity.

Contributions from nutritionists and epidemiologists will be included, with a panel discussion focused on the connection between cancer and obesity and what we can do about it – both by understanding the link and by tackling obesity with scientifically informed strategies. Please submit your question for the speakers on the panel.

All registrants are invited to submit abstracts for oral and poster presentations. Register by the 21st March 2012 and benefit from the reduced early-bird registration fees.
+ show speakers and program
Tuesday 29th May 2012
Day One

15:30 - 17:00


17:00 - 18:00

Introduction - Matthew Cockerill,
BioMed Central

Leptin and the physiological circuitry of weight control
Jeffrey Friedman, The Rockefeller University, USA

18:00 – 20:00

Poster session with drinks

Wednesday 30th May 2012
Day Two

08:30 - 10:15

Session 1. Adipogenesis and insulin resistance. Chair: Richard Bergman


Irisin and the therapeutic benefits of exercise
Bruce Spiegelman, Harvard Medical School and Dana-Farber Cancer Institute, USA

Barbara Kahn, Harvard Medical School and Beth Israel Deaconess Hospital, USA

Obesity, insulin resistance, and the pathway to type 2 diabetes
Richard Bergman, Cedars-Sinai Medical Center, Los Angeles, USA

10:15 - 10:45


10:45 - 12:15

Session 2. Metabolism and mechanism. Chair: Christopher Newgard

Regulation of nutrient metabolism by nuclear receptor/FGF signaling pathways
David Mangelsdorf, University of Texas Southwestern Medical Center, USA

Finding mechanism from metabolic signatures of disease
Christopher Newgard, Duke University Medical Center, USA

Does fructose play a role in metabolic disorders?
Luc Tappy, University of Lausanne, Switzerland

12:15 - 13:15


13:15 - 15:00

Session 3. Metabolism and the cancer cell. Chair: Michael Pollak


Beyond insulin: rethinking cellular metabolism
Craig Thompson, Memorial Sloan-Kettering Cancer Center, USA

Energy input and cancer risk at the cellular and whole organism level: modification by metformin
Michael Pollak, McGill University and Jewish General Hospital, Canada

Growth control and metabolism
David Sabatini, Massachusetts Institute of Technology, USA

15:00 - 15:30


15:30 - 17:00

Session 4. Linking diabetes and cancer. Chair: Lewis Cantley

PI 3-kinase and disease
Lewis Cantley, Harvard Medical School and Beth Israel Deaconess Medical Center, USA

AMPK - a nutrient and energy sensor with roles in diabetes, cancer and viral infection
Grahame Hardie, University of Dundee, UK

+ talks selected from abstracts

17:00 - 19:00

Posters with drinks


Surviving starvation: essential role of the ghrelin-growth hormone axis
Joseph L. Goldstein, University of Texas Southwestern Medical Center, USA

Conference dinner

Thursday 31 May 2012
Day Three

9:00 - 12:00

Session 5. Epigenetics, metabolism and aging. Chair: Leonard Guarente

Sirtuin activators as interventions for healthy aging
Rafael de Cabo, National Institutes on Aging, NIH, USA

Sirtuins, aging and metabolism
Leonard Guarente, Massachusetts Institute of Technology, USA

10:00 - 10:30


Up, down, and all around the epigenomic regulation of metabolism
Mitchell Lazar, University of Pennsylvania, USA

Regulation of metabolism by sirtuins
Marcia Haigis, Harvard Medical School, USA

+ talks selected from abstracts

12:00 - 13:00


13:00 - 15:00

Session 6. Diet and nutrition: health policy and practice. Chair: Stephen Hursting

Energy balance, metabolism and cancer: mechanistic insights from transdisciplinary studies
Stephen Hursting, University of Texas and MD Anderson Cancer Center, USA

Excess body weight, diabetes and cancer: epidemiologic evidence implicating hormonal and metabolic mechanisms
Rudolf Kaaks, German Cancer Research Center, Germany

Carbohydrate restriction uniquely benefits metabolic syndrome and saturated fat metabolism
Jeff Volek, University of Connecticut, USA

Linda Nebeling, National Cancer Institute, USA

15:00 - 15:30


15:30 - 17:30

Panel discussion:
What is the obesity-cancer connection? And what can we do about it?

Speakers plus:
Gregory Petsko, Brandeis University, USA – Chair
Gary Taubes, Robert Wood Johnson Foundation Independent Investigator in Health Policy Research at the U.C. Berkeley School of Public Health

29 May - 31 May 2012
Washington DC
United States of America
meeting website