RNA regulators of gene expression

Meeting background

Our understanding of the role played by RNA molecules in the control of gene expression has evolved rapidly within recent years. Novel regulatory RNA elements have been identified in both eukaryota and prokaryota, including siRNAs, piRNAs, miRNAs, sRNAs, CRISPRs, riboswitches and RNA thermometers. These elements can fine tune mRNA metabolism according to the output of complex signalling networks or may provide simple on/off switches that respond to macroscopic changes in the cellular environment (e.g. temperature). They vary in size, in structure and in functional mechanism.

Although important differences exist in the RNA regulation of prokaryota and eukaryota, parallels are starting to emerge. The aim of this meeting is to provide a forum to discuss both parallels and differences, achieving a better understanding of the role of RNA in regulating gene expression.

The speakers of this Harden conference will discuss their work on RNA-based regulation in different organisms. Scientists in the audience, also working on a diverse range of systems, will take on the discussion in two poster sessions and informal events.
+ show speakers and program
Kristine Arnvig (MRC-NIMR, United Kingdom)
Andres Ramos (MRC-NIMR, United Kingdom)
Portland Press Limited
National Institute for Medical Research
Nature Structural & Molecular Biology
Anton Wutz (Wellcome Trust, United Kingdom)
Cathy Squires (Tufts Medical School, U.S.A)
Computational methods for finding, aligning and analyzing long non coding RNAs
Cedric Notredame (Biocat, Spain)
Maturation of small interfering RNAs in the CRISPR/Cas adaptive immune system
Emmanuelle Charpentier (Umeå University, Sweden)
Eric Miska (University of Cambridge, United Kingdom)
Eugene Koonin (National Institute of Health, U.S.A)
George Salmond (University of Cambridge, United Kingdom)
Gerhart Wagner (University of Uppsala, Sweden)
Herve Vaucheret (Institut Jean-Pierre Bourgin, France)
Regulation of mammalian transcription by non-coding RNAs
James Goodrich (University of Colorado, U.S.A)
Deep sequencing based discovery of small noncoding RNAs in bacteria
Jörg Vogel (University of Würzburg, Germany)
Regulating a regulator: RNA-mediated control of the virulence activator PrfA in Listeria monocytogenes
Jörgen Johansson (Umeå University, Sweden)
Non-coding RNAs: the art of epigenetically modulating gene transcription in human cells
Kevin Morris (The Scripps Research Institute, U.S.A)
microRNAs in cancer
Martin Bushell (University of Leicester, United Kingdom)
Biogenesis of PIWI-interacting RNAs in Drosophila
Mikiko Siomi (Keio University School of Medicine, Japan)
Poul Valentin-Hansen (University of Southern Denmark, Denmark)
Reuven Agami (The Netherlands Cancer Institute, The Netherlands)
Functional consequences of KSRP-dependent miRNA biogenesis
Roberto Gherzi (National Institute for Cancer Research, Italy)
Shoshy Altuvia (Hebrew University, Israel)
Mechanism and regulation of miRNA-mediated repression in metazoa
Witold Filipowicz (Friedrich Miescher Institute for Biomedical Research, Switzerland)

22 Jul - 25 Jul 2012

United Kingdom
meeting website