Lipid Protein Interactions in Membranes: Implications for Health and Disease

Membrane proteins occupy a central role in cellular physiology. Almost 50% of all proteins encoded by a eukaryotic genome are membrane proteins. As a result, ~50% of biological processes take place on membranes.

This meeting, which will take place in the Centre for Cellular and Molecular Biology (CCMB), Hyderabad, India, will focus on contemporary issues in this area with special emphasis on lipid interactions of membrane proteins and possible implications in health and disease. Breakthroughs in membrane protein research has been rather slow in the past due to technical difficulties in crystallizing membrane proteins and lack of appropriate techniques to monitor lipid-protein interactions in situ in natural membranes. Tremendous advances in membrane protein crystallography in the last few years, coupled with powerful molecular dynamics and microscopic approaches, have started to changethis scenario. It is against this backdrop that this thematic meeting is taking place.

Bringing together the minds of leading researchers across
various areas of contemporary membrane research will
provide novel information and insight into membrane
processes. This may help to develop robust models
for function and interaction of membrane proteins,
while enhancing our ability to design better
therapeutic strategies to combat diseases
related to malfunctioning of membrane
proteins and receptors.
+ show speakers and program
Mibel Aguilar, Monash University, Australia
Defining the Mechanism of Peptide-Membrane Interactions through Membrane Structure Change and Recovery

John E. Baenziger, University of Ottawa, Canada
Lipids as Allosteric Modulators of the Nicotinic Acetylcholine Receptor: From Model Bilayers to Synapic Function

B. George Barisas, Colorado State University, USA
Nanoparticle Probes of Molecular Motions on Cell Surfaces

Francisco J. Barrantes, Pontificia Universidad Católica, Argentina
To Be Announced.

Andrew Brown, University of New South Wales, Australia
How is Cholesterol sensed to Maintain its Qwn Homeostasis?

Amitabha Chattopadhyay, Centre for Cellular & Molecular Biology, India
GPCR-cholesterol Interaction: A Multidimensional Approach

Andrew H. Clayton, Swinburne University, Australia
Protein-protein and Protein-lipid Interactions Probed using the Many Dimensions of Fluorescence

Diego de Mendoza, Universidad National de Rosario, Argentina
Mechanisms of Signaling and Regulation of Membrane Properties by a Bacterial Thermosensor

William Dowhan, University of Texas Medical School at Houston, USA
Protein Gymnastics in the Lipid Bilayer: Lipids as Determinants of Protein Structure & Function

Sadashiva Karnik, Cleveland Clinic, USA
Fishing with the Angiotensin Receptors

Antoinette Killian, Utrecht University, The Netherlands
Synthetic Transmembrane Peptides as Models for Membrane Proteins

Toshihide Kobayashi, RIKEN, Japan
Sphingomyelin domains Control the Formation of Phosphatidylinositol-4,5-Bisphosphate Clusters during Cytokinesis

Roger E. Koeppe, II, University of Arkansas, USA
Assessing Single Residue Ionization and Contribution to Lipid-Protein Interactions

Rachel S. Kraut, Nanyang Technological University, Singapore
Optically Invisible Properties of Membrane Organization are revealed by TIRF-FCS on a Sphingolipid-Interacting Probe

Akihiro Kusumi, Kyoto University, Japan
To Be Announced.

Barry Lentz, University of North Carolina at Chapel Hill, USA
To Be Announced.

Irena Levitan, University of Illinois, Chicago, USA
Mechanisms of Cholesterol Regulation of Inwardly-Rectifying K Channels

Erwin London, State University of New York, USA
To Be Announced.

Boris Martinac, Victor Chang Cardiac Research Institute, Australia
Lipid Effects on the Mechanosensitivity of MscL and LscS co-reconstituted into Liosomes

Frederick R. Maxfield, Weill Cornell Medical College, USA
Transport of Cholesterol into and within Cells

Hassane S. Mchaourab, Vanderbilt University, USA
Conformational Cycles of Active Transporters in Lipid Bilayers

Paul O'Shea, University of Nottingham, UK
Protein-protein Interactions in Fluid and Raft-Like Membrane Domains; Solutions to the Inverse Problem

Manuel J. Prieto, Instituto Superior Técnico, Portugal
Amyloid-like Fiber Formation Driven by Lipid-protein Interaction: Structure and Dynamics from homo-FRET, FLIM and FCS

Thomas Pucadyil, IISER, India
Membrane Fission Catalyzed by the Dynamin Family of Proteins

Jean-Marie Ruysschaert, Free University of Brussels, Belgium
Emerging Roles for Lipids in Structure and Function of Multidrug Transporters

Thomas P. Sakmar, Rockefeller University, USA
Probing Receptor Function using Unnatural Amino Acid Mutagenesis

Laurence Salome, CNRS, France
Mu Opioid Receptors: Functional State and Dynamic Organization in the Membrane

Durba Sengupta, National Chemical Laboratory, India
Influence of Cholesterol on Membrane Receptor Dynamics and Association

Frances Separovic, University of Melbourne, Australia
Membrane Interactions of Amyloid Abeta 42 Peptide from Alzheimer’s Disease

Robert M. Stroud, University of California, San Francisco, USA
To Be Announced.

Musty J. Swamy, University of Hyderabad, India
Lipid-Protein Interactions and Chaperone Activity of the Major Protein of Bovine Seminal Plasma, PDC-109

Lukas K. Tamm, University of Virginia Health Sciences Centers, USA
Structure, Function, and Antibiotic Resistance of the Outer Membrane of Pseudomonas Aeruginosa
Gregory A. Voth, University of Chicago, USA
Membrane Remodeling by Proteins

Anthony Watts, University of Oxford, UK
To Be Announced.

Felix Wieland, Heidelberg University, Germany
To Be Announced.

1 Nov - 5 Nov 2012

meeting website