Annual Symposium: Epigenetic mechanisms in development and disease

Epigenetic mechanisms, including the posttranslational modifications of chromatin (DNA and histones), play pivotal roles in development, cell differentiation and cell identity. Inappropriate regulation of epigenetic mechanisms has been implicated in common human diseases such as diabetes, neuropsychiatric disorders and cancers. Environmental influences such as nutrition and stress can lead to epigenetic alterations and contribute to chronic disease biology.

Since the original epigenetic mark on DNA, cytosine methylation, was discovered there has been many posttranslational marks on histone proteins shown to have a functional impact on controlling gene expression in development and disease processes. Much progress has been made in understanding the biochemistry of such modifications though there is still far to go before we understand the functional impact and combinatorial roles of the modifications within an organism. Recent advances in technology have made genome-wide of studies of modifications feasible providing rich datasets on the epigenomes of individual cell states.

This meeting will encompass our current understanding of the role of cytosine methylation, as well histone modifications and the recently identified cytosine hydoxymethylation. There will be a focus on understanding how epigenetic marks regulate development and normal physiological functions in addition to the contribution they make to disease progression. The use of new technologies to interrogate epigenetic landscapes and their potential for future discoveries will be also be highlighted.

+ show speakers and program
Adele Murrell (Cancer Research UK, United Kingdom)
Paul Hurd (Queen Mary, University of London, United Kingdom)
Ian Wood (University of Leeds, United Kingdom)

The role of imprinted genes in brain function and neurodevelopmental disease
Anthony Isles (University of Cardiff, United Kingdom)
Antonis Kirmizis (University of Cyprus, Cyprus)
Transcriptional control of lineage commitment in embryonic stem cells
Brian Hendrich (University of Cambridge, United Kingdom)
Chromatin control by prolyl-isomerases
Chris Nelson (University of Victoria, Canada)
Petra Hajkova (MRC Clinical Sciences Centre, United Kingdom)
Ramin Shiekhattar (Wistar Institute, U.S.A.)
Rob Klose (University of Oxford, United Kingdom)
Rosalind John (Cardiff University, United Kingdom)
Histone deacetylases (HDAC) 1 and 2 regulate T-cell development
Shaun Cowley (University of Leicester, United Kingdom)
EWAS: the new kid on the block for epigenome-wide association studies
Stephan Beck (University College London, United Kingdom)
Transgenerational inheritance of non-genetically determined phenotypes
Vardhman Rakyan (Barts and The London School of Medicine and Dentistry, United Kingdom)
Epigenetic reprogramming in mammalian development
Wolf Reik (Babraham Institute, United Kingdom)

11 Dec - 13 Dec 2012
United Kingdom
meeting website