G-protein-coupled-receptors: from structural insights to functional mechanisms

A two-day meeting based at Prato in Italy, which will consider recent advances in G-protein coupled receptor structure and function, building on new concepts arising from biophysics, crystallography, pharmacology and cell biology

Crystal structures of family A GPCRs
Ligand binding and activation of family A GPCRs
Ligand binding and activation of family B GPCRs
Novel ligands for GPCRs and drug design
RAMPs and other accessory proteins
GPCR oligomerisation
Trafficking of GPCRs
GPCR signalling to ion channels
Single molecule studies of GPCRs
+ show speakers and program
Regulation of GABAB receptors by auxiliary subunits
Bernhard Bettler (University of Basel, Switzerland)
Bice Chini (CNR, Italy)
Structural insights into the dynamic process of G protein coupled receptor signaling
Brian Kobilka (Stanford University School of Medicine, U.S.A.)
Delineating the complexity of biased and full agonism reveals the existence of a new distinct active AT1 receptor entity: toward a redefinition of “biased agonist”
Céline Gales (Inserm/UPS UMR 1048 - I2MC, France)
Common and distinct features of agonist activation of the adenosine A2A receptor and b-adrenoceptors
Chris Tate (MRC, United Kingdom)
Ligand binding and activation of the CGRP receptor; a novel family B GPCR
David Poyner (Aston University, United Kingdom)
A new generation of orexin receptor antagonists discovered using structure based drug design
Fiona Marshall (Heptares Therapeutics, United Kingdom)
Jean-Louis Banères (University of Montpellier, France)
Laurence Miller (Mayo Clinic, U.S.A.)
Immunoreceptor tyrosine-based inhibitory motifs (ITIMs) in GPCRs: The OX1 receptor case and beyond
Marc Laburthe (Inserm U773, France)
Nigel Bunnett (Monash University, Australia)
Understanding allosteric drug action and signal bias at the GLP-1 receptor
Patrick Sexton (Monash University, Australia)
Rob Leurs (Vrije Universiteit Amsterdam, Netherlands)
Thierry Durroux (CNRS Montpellier, France)

12 Sep - 14 Sep 2012

meeting website