Hematopoiesis is the process by which hematopoietic stem cells self-renew and differentiate to form the peripheral blood lineages. This meeting seeks to develop a broad view of this process in terms of the self-renewal process, development of the hematopoietic system, and differentiation. Plenary sessions will encompass the birth of hematopoietic stem cells all the way through development of mature cell lineages throughout adult life. They will include sessions on developmental hematopoiesis that will explore the birth of the blood system in embryos, sessions on adult stem cell self-renewal, and sessions on stem cell niches and novel hematopoietic regulators. Particularly exciting areas of research that will be covered in the meeting include the identification of new growth factors that enhance stem cell decisions, advances in our understanding of transcription mechanisms using new genetic and genomic technologies, and new epigenetic mechanisms that regulate leukemic stem cell populations. The meeting will also address drug strategies that are being developed for clinical trials. Taken together, we anticipate that this conference will yield novel insights into the biology and potential therapeutic uses of hematopoietic stem cells and their progeny for the control of cancer and disease.
+ show speakers and program
MONDAY, JANUARY 14
15:00—19:30
Arrival and Registration
Foyer
TUESDAY, JANUARY 15
07:00—08:00
Breakfast
Foyer
08:00—11:00
Developmental Hematopoiesis Including ES and iPS to Blood
Registered attendees can view abstracts starting on 12/14/2012
Storm Peak/Mt. Werner
Catherine Porcher, University of Oxford, UK
The SCL Complex and Hematopoiesis
Nancy A. Speck, University of Pennsylvania, USA
Hematopoietic Commitment Mediated by Runx1
Elaine A. Dzierzak, Erasmus University, Netherlands
The Developmental Origins of Adult HSCs
Gordon M. Keller, University Health Network, MaRS Centre, Canada
Multiple Waves of Hemogenic Endothelium from ES Cells
Short Talk(s) Chosen from Abstracts
09:20—09:40
Coffee Break
Foyer
11:00—13:00
Poster Setup
Sunshine
13:00—22:00
Poster Viewing
Sunshine
On Own for Lunch and Recreation
14:30—16:30
Workshop 1: Stem Cell Self-Renewal
Storm Peak/Mt. Werner
Short Talks Chosen from Abstracts
16:30—17:00
Coffee Available
Foyer
17:00—18:30
Novel Hematopoietic Regulators
Registered attendees can view abstracts starting on 12/14/2012
Storm Peak/Mt. Werner
Leonard I. Zon, HHMI/Children's Hospital Boston, USA
Pathways Regulating Blood Stem Cell Self-Renewal and Engraftment
David Traver, University of California, San Diego, USA
Novel Signals Controlling Stem Cell Development in Zebrafish
Sean J. Morrison, HHMI/University of Texas Southwestern Medical Center, USA
Metabolism and Stem Cells
Short Talk Chosen from Abstracts
18:30—19:30
Keynote Address
Registered attendees can view abstracts starting on 12/14/2012
Storm Peak/Mt. Werner
George Q. Daley, Children's Hospital Boston, USA
Milestones and Barriers in HSC Production from ES or iPS Cells
19:30—20:30
Social Hour w/ Lite Bites
Sunshine
19:30—22:00
Poster Session 1
Sunshine
WEDNESDAY, JANUARY 16
07:00—08:00
Breakfast
Foyer
08:00—11:00
Adult Stem Cell Self-Renewal and Function
Registered attendees can view abstracts starting on 12/14/2012
Storm Peak/Mt. Werner
Emmanuelle Passegué, University of California, San Francisco, USA
Self-Renewal and DNA Repair
Amy J. Wagers, Harvard University, USA
Local and Systemic Regulation of Blood Stem Cell Function throughout Life
Margaret A. Goodell, Baylor College of Medicine, USA
HSCs during Stress and Host Defense
Daniel G. Tenen, Harvard Stem Cell Institute, Boston, USA and Cancer Science Institute, Singapore
Regulation of Myeloid Transcription Factors and Methylation by Long Noncoding Intragenic RNAs
Short Talk(s) Chosen from Abstracts
09:20—09:40
Coffee Break
Foyer
11:00—13:00
Poster Setup
Sunshine
13:00—22:00
Poster Viewing
Sunshine
On Own for Lunch and Recreation
16:30—17:00
Coffee Available
Foyer
17:00—19:00
Microenvironment
Registered attendees can view abstracts starting on 12/14/2012
Storm Peak/Mt. Werner
David T. Scadden, Massachusetts General Hospital and Harvard University, USA
Function of the Niche in Self-Renewal of HSCs
Toshio Suda, Keio University, Japan
A Metabolic Guide to Stem Cell Homeostasis
Michael P. Cooke, Genomics Institute of the Novartis Research Foundation, USA
Regulation of HSC Self-Renewal by the Aryl Hydrocarbon Receptor
Short Talk Chosen from Abstracts
19:00—20:00
Social Hour w/ Lite Bites
Sunshine
19:30—22:00
Poster Session 2
Sunshine
THURSDAY, JANUARY 17
07:00—08:00
Breakfast
Foyer
08:00—11:00
Erythroid and Megakaryocyte Development
Registered attendees can view abstracts starting on 12/14/2012
Storm Peak/Mt. Werner
Stuart H. Orkin, Dana-Farber Cancer Institute, USA
Regulation of Globin Gene Switching
Mitchell J. Weiss, Children’s Hospital of Philadelphia, USA
Erythroid and Megakaryocytic Gene Expression and miRNAs
Harvey Lodish, Whitehead Institute for Biomedical Research, USA
The Terminal Stages of Red Cell Development
Hanna K. A. Mikkola, University of California, Los Angeles, USA
Specification and Self-Renewal of Hematopoietic Stem Cells
Short Talk(s) Chosen from Abstracts
09:20—09:40
Coffee Break
Foyer
11:00—13:00
Poster Setup
Sunshine
13:00—22:00
Poster Viewing
Sunshine
On Own for Lunch and Recreation
14:30—16:30
Workshop 2: Differentiation of Hematopoietic Cells
Storm Peak/Mt. Werner
Short Talks Chosen from Abstracts
16:30—17:00
Coffee Available
Foyer
17:00—19:00
Hematopoietic Cell Differentiation and Function
Registered attendees can view abstracts starting on 12/14/2012
Storm Peak/Mt. Werner
Bertie Gottgens, Cambridge Institute for Medical Research, UK
Combinatorial Control of Lineage Commitment
Meinrad Busslinger, Research Institute of Molecular Pathology, Austria
Transcriptional Control of Early Lymphopoiesis
Irving L. Weissman, Stanford University, USA
Myeloid Cells and Don't Eat Me Signal
Short Talk Chosen from Abstracts
19:00—20:00
Social Hour w/ Lite Bites
Sunshine
19:30—22:00
Poster Session 3
Sunshine
FRIDAY, JANUARY 18
07:00—08:00
Breakfast
Foyer
08:00—11:00
Leukemogenesis
Registered attendees can view abstracts starting on 12/14/2012
Storm Peak/Mt. Werner
Ross L. Levine, Memorial Sloan-Kettering Cancer Center, USA
Role of Mutations in Epigenetic Modifiers in Myeloid Malignancies
Scott A. Armstrong, Children's Hospital Boston, USA
Molecular Characterization of Leukemia Stem Cell Self-Renewal
John E. Dick, Toronto General Research Institute, University Health Network, Canada
Toward Unification of the Genetic and Cancer Stem Cell Models of Leukemia
Anjana Rao, La Jolla Institute for Allergy and Immunology, USA
Modification of DNA Cytosine Methylation by TET Proteins
Short Talk(s) Chosen from Abstracts
09:00—09:20
Coffee Break
Foyer
On Own for Lunch and Recreation
16:30—17:00
Coffee Available
Foyer
17:00—19:00
Lymphoid
Registered attendees can view abstracts starting on 12/14/2012
Storm Peak/Mt. Werner
Avinash S. Bhandoola, University of Pennsylvania, USA
Establishing T Cell Identity
Sten Erik W. Jacobsen, University of Oxford, UK
Origin of Lymphoid Lineages
Ellen Rothenberg, California Institute of Technology, USA
Sequential Operation of Gene Regulatory Networks in the Stem Cell to T Cell Commitment Process
Short Talk Chosen from Abstracts
19:00—20:00
Social Hour w/ Lite Bites
Sunshine
20:00—23:00
Entertainment
Sunshine
SATURDAY, JANUARY 19
Departure
*Session Chair †Speaker invited, not yet responded.
