Cell division: From single molecule mechanics to whole organisms

Cell cycle research today is sustained through crucial technological advances, most notably in the area of imaging but also in the area of very high-resolution analyses of biological specimens. The technological exploitation of fluorescent proteins revolutionized the way one can now study cell cycle genes. Besides allowing studies on the localization and cellular dynamics of cell cycle gene products, this approach is currently supporting the explosion of single molecule studies. Coupled with in vitro reconstitution approaches, for instance, these studies have recently led to the reconstitution of multi-component protein systems capable of establishing stable steady-state driven by ATP consumption in vitro. In the meantime, genetic tools to study cell cycle genes in multicellular organisms considerably improved. This allows drawing an integrated picture of the role of cell cycle genes during development, growth and cancer. Chemical genetics is very favorably influencing our way of carrying out experiments in the short timeframe of cell cycle events, such as mitosis, without interfering with other cell cycle phases, and therefore achieving much more accurate phenotypic consequences.

The purpose of this conference is to bring together scientists fascinated by cell division, but who approach the problem from different perspectives due to their different backgrounds and expertise. This requires the contribution of physicists, which keep developing new techniques to dissect the mechanics of enzymes, biochemists and structural biologists, who are in the midst of reconstituting complex cell cycle multi-protein modules, chemists who are developing more and more specific inhibitors of key enzymes such as molecular motors and kinases, physiologists who are starting to describe how cell cycle gene perturbations affect certain tissues, and medical doctors who are exploring how cell cycle perturbations promote cancer.
+ show speakers and program
ABRIEU Ariane (Montpellier, France)
Mitosis: to split or to die

BARFORD David (London, United Kingdom)
Structural analysis of APC/C assembly and degron recognition

BARRAL Yves (Zürich, Switzerland)
Coordination of cytoskeletal events during mitosis

BASTO Renata (Paris, France)
Investigating the contribution of centrosome amplification to aneuploidy and tumourigenesis

CHEESEMAN Iain (Cambridge, USA)
Building a dynamic kinetochore-microtubule interface

Catalytic generation of the mitotic checkpoint inhibitor that blocks ubiquitination and degradation of cyclin B

ELLENBERG Jan (Heidelberg, Germany)
Multipolar spindle assembly and error-prone chromosome bi-orientation in the first meiotic division of mouse oocytes

GLOTZER Michael (Chicago, USA)
Control of cortical contractility during cytokinesis

GONZALEZ Cayetano (Barcelona, Spain)
The contribution of germline proteins to somatic cancer

HIROTA Toru (Tokyo, Japan)
How abruptness of chromosome segregation is ensured in mammalian cells

HYMAN Tony (Dresden, Germany)
Mesoscale organization of cytoplasm during the cell cycle

JALEPALLI Prasad (New York, USA)
Making and breaking the 'wait anaphase' signal

JAVERZAT Jean-Paul (Bordeaux, France)
The establishment of sister-chromatid cohesion in fission yeast

KARESS Roger (Paris, France)
RZZ and the Kinetochore

LORCA Thierry (Montpellier, France)
How Greatwall and its substrates control the cell cycle

MALUMBRES Marco (Madrid, Spain)
Genetic analysis of mammalian mitotic kinases

McAINSH Andrew (Coventry, United Kingdom)
How to power chromosome movement

MEIJER Laurent (Roscoff, France)
Pharmacological inhibitors of CDKs: convergence of effects on the MYC pathway

MUSACCHIO Andrea (Dortmund, Germany)
Molecular basis of chromosome segregation

PELLMAN David (Boston, USA)
DNA Breaks and Chromosome Pulverization from errors in mitosis

PIATTI Simonetta (Montpellier, France)
Septin dynamics in the control of budding yeast mitotic exit and cytokinesis

PIEL Matthieu (Paris, France)
Forces and Cell Division

PINES Jon (Cambridge, United Kingdom)
How the Spindle Assembly Checkpoint regulates the APC/C

STUKENBERG Todd (Charlottesville, USA)
Mitotic regulation of kinetochores

SURREY Thomas (Londres, United Kingdom)
The structural basis of microtubule plus end tracking

TAYLOR Stephen (Manchester, United Kingdom)
Switching on and off the spindle checkpoint

VERLHAC Marie-Hélène (Paris, France)
Control of asymmetric divisions in acentriolar meiosis

WASSMANN Katja (Paris, France)
Correct chromosome segregation in mouse oocyte meiosis

5 Sep - 9 Sep 2012
meeting website