10th International Workshop on Pathogenesis and Host Response in Helicobacter Infections

ESGPIHI was founded in Copenhagen in 1992 as the European Pathogenesis and Immunology Study Group by scientists working on Helicobacter infections with the main purpose of stimulating the collaboration between scientific groups. One approach to realize this goal is to arrange basic science meetings on pathogenesis and immunology. Pathophysiology, diagnosis, antimicrobial agents and susceptibility testing are not the main subjects of the meetings although basic mechanisms in these fields are borderlines to the workshop.
The first open meeting of the group was in Helsingør, Denmark in 1994 followed by Galway, Ireland 1997 and Helsingør 1998, 2000, 2002, 2004, 2006, 2008 and 2010.
The 2012 Helicobacter workshop in Helsingør will also deal with:

Motility, adhesion and colonization of Helicobacter species
Molecular mechanisms and inflammation
Molecular genetics and virulence factors
Cellular and humural immune response and vaccines
Interactions between host cells and Helicobacter spp.
Carcinogenesis in Helicobacter infections
New Helicobacter species and extragastric Helicobacter infections
Experimental animal models
Basic mechanisms of helicobacters and probiotics
Metabolisms and treatment targets in Helicobacter infections
+ show speakers and program
Wednesday July 4, 2012
12.00: Poster set up and registration

15.00: Welcome address
Leif Percival Andersen, Copenhagen, Denmark

Session: In memoriam of Anthony Moran, Ireland (15.15 - 17.30)
Chair: Sebastian Suerbaum, Germany & Leif P. Andersen, Denmark

Tony and Campylobacter research
Manfred Kist, Freiburg, Germany
Tony and Helicobacter research
Torkel Wadström, Lund, Sweden
The Anthony Moran memorial lecture (16.00 - 16.45)
Ben Appelmelk, Amsterdam, The Netherlands
Abstract presentations (16.45-17.30)

HP-33: Analysis of the role of O-antigen adhesion to DC-SIGN and galectin-3 in the immune response to Helicobacter pylori.
Warren Flood, Manchester, UK
HP-36. In Vitro and In Vivo Evaluation of the Anti-Adhesive Effect of Milk Fat Globule Membrane Glycoproteins on Helicobacter pylori.
Tessa Horemans, Wilrijk Belgium.
HP-48: Helicobacter pylori switches the host cells glycosylation pathways to remodel the gastric mucosa glycophenotype.
Ana Magalhães, Porto, Portugal.

18.00: Dinner

19.00: Poster viewing etc.

19.30: Business meeting (Room B-21)

Thursday July 5, 2012

Session 1: Mucus and extracellular matrix (08.30 - 10.00)
Chair: Sara Lindén, Sweden & Karen Robinson, UK


The role of the mucus barrier in protection against infection with intestinal dwelling nematodes.
David Thornton, Manchester, UK
Abstract presentations:

HP-04: Human gastric mucins differently regulate Helicobacter pylori proliferation, gene expression and interactions with host cells
Emma Skoog, Gothenburg, Sweden
HP-05: Helicobacter pylori infection impair mucin production rate and turn over in the murine gastric mucosa
Nazanin Navabi, Gothenburg, Sweden
HP-16: Promoter hypermethylation of multiple genes in association with early stage of H. pylori infection
Marisa Alvarez, SP, Brazil
HP-19: Role of the proposed Helicobacter pylori energy sensor TlpD in vivo and characterization of protein-protein interactions of TlpD
Wiebke Behrens, Hannover, Germany
HP-55: Polymorphism and adaptation in pH-regulated H. pylori adherence.
Jeanna Bugaytsova, Umeå, Sweden.

10.00: Coffee/TeaBreak

Session 2: Adhesion and virulence factors (10.30 - 12.00)
Chair: Thomas Boren, Sweden & Rainer Haas, Germany


Towards the structural basis of CagA translocation.
Laurent Terradot, Lyon, France
Abstract presentations:

HP-01: Helicobacter pylori possesses 4 coiled coil rich proteins (Ccrp) that form extended filamentous structures and control cell shape and motility.
Sarah Schätzle, Freiburg, Germany
HP-23. HtrA: a new secreted virulence factor in bacterial infections.
Silja Wessler, Salzburg, Austria
HP-25: Induction of host cell resistance to CagA translocation of Helicobacter pylori by co-incubation experiments.
L.F. Jiménez-Soto, Munich, Germany
HP-37: NorH, the first nitric oxide reductase of Helicobacter pylori.
Marta Justino, Oeiras, Portugal
HP-39: The H. pylori cagPAI expresses a novel effector-like protein which targets human ubiquitin and related small modifiers.
Christina Josenhans, Hannover, Germany

12.00: Lunch

Poster sessions (13.00 - 14.00)
Poster session 1: Colonization and virulence factors
Chair: Torkel Wadström, Sweden & Christine Josenhans, Germany.
Poster session 2: Inflammation, immunology and vaccines
Chair: Mario D’Elios, Italy & Dionyssios Sqouras, Greece.

Session 3: Inflammation and immunity (14.00 - 15.30)
Chair: John Nedrud, USA & Phil Sutton, Australia


Helicobacter pylori targets dendritic cells to induce immune tolerance, promotepersistence and confer protection against allergic asthma.
Anne Müller, Zurich, Switzerland
Abstract presentations:

HP-11. Gastric migration of regulatory T-cells, mediated via the chemokine CCL20and its receptor CCR6, in Helicobacter pylori infected humans and mice.
Katherine W. Cook, Nottingham, UK.HP-13.
Helicobacter γ-glutamyltranspeptidase inhibits T cell proliferation via glutaminedepletion.
Stefanie Wüstner, Munich, Germany.
HP-46. Identification of immunomodulatory molecules from Helicobacter pylori, andtheir role during infection.
Anzel Borgel Greenaway, Nottingham, UK.
HP-69. Involvement of the inflammasome in infection with Helicobacter pylori.
Raphaela Semper, Munich, Germany.
HP-72. Helicobacter pylori induces LTβR signaling in gastric cells.
Raquel Mejias-Luque, Munich, Germany.

15.30: Coffee/Tea break

Session 4: Immune response and vaccines (16.00 - 17.30)
Chair: Jay Solnick, USA & Open


Individual differences and the outcome of infectious diseases
Jay Solnick, Davis, USA
Abstract presentations:

HP-03. PAR2 Promotes Vaccine-Induced Protection against Helicobacter Infection in Mice.
Dominique Velin, Lausanne, Switzerland.
HP-09. Protective efficacy of recombinant Helicobacter suis proteins against Helicobacter suis challenge in a mouse model.
Miet Vermoote, Ghent, Belgium.
HP-42. Helicobacter pylori platform technology (HPPT) for vaccine delivery: Phase I safety and immunogenicity data of candidate H. pylori recipient strains.
A. Fulurija, Western Australia, Australia.
HP-47. Mucosal immunization with H. pylori adhesins confers therapeutic immunity in primates.
Lena Rakhimova, Umeå, Sweden.

18.00: Dinner

19.30: Buses are leaving for Kronborg, castle of Hamlet.

Friday July 6, 2012

Session 5: Non-pylori and extra-gastric manifestations (08.30 - 10.00)
Chair: Freddy Haesebrouck, Belgium & Hazel Mitchell, Australia


New insights in gastric non-pylori Helicobacters.
Freddy Haesebrouck, Gent, Belgium
Abstract presentations:

HP-07. The putative contingency nature of Helicobacter bizzozeronii NAD(P)H-nitroreductase HBZC1_00960.
Pradeep Kondadi, Helsinki, Finland.
HP-27. Colonization capacity of Helicobacter heilmannii sensu stricto isolates in a Mongolian gerbil model.
Annemieke Smet, Ghent, Belgium.
HP-28. Modulation of Helicobacter suis-induced inflammation by glutamine and reduced glutathione.
Bram Flahou, Ghent, Belgium.
HP-34. Susceptibility of IL-10 deficient mice to Helicobacter hepaticus-induced colitis depends on intestinal microbiota composition.
I. Yang, Hannover, Germany.
HP-64. Helicobacter pullorum - A potential gastrointestinal pathogen?
Hazel Mitchell, New South Wales, Australia.

10.00: Coffee/Tea break

Session 6: "-OMICS" (10.30 - 12.00)
Chair: Arnoud van Vliet, UK & Sebastian Suerbaum, Germany


Gut microbiotica.
Paul O’Toole, Cork, Ireland
Abstract presentations:

HP-06. Genome-wide survey of mutual homologous recombination in H. pylori.
Ichizo Kobayashi, Tokyo, Japan.
HP-08. Genomics and microevolution dynamics of human-derived Helicobacter bizzozeronii.
Mirko Rossi, Helsinki, Finland.
HP-14. The nucleotide excision repair (NER) system of Helicobacter pylori: Role in mutation prevention and chromosomal import patterns after natural transformation.
Juliane Krebes, Hannover, Germany.
HP-52. Small Regulatory RNAs in Helicobacter pylori and Campylobacter jejuni.
Cynthia Sharma, Würzburg, Germany.
HP-75. Genomic Structure and Diversity of Helicobacter pylori strains from Malaysia.
S. P. Gunaletchumy, Kuala Lumpur, Malaysia.

12.00: Lunch

Poster sessions (13.00 - 14.00)
Poster session 3: OMICS and extra gastric manifestations
Chair: Hilde De Reuse, France & Henrik Permin, Denmark
Poster session 4: Basic mechanisms and carcinogenesis
Chair: Markus Gerhardt, Germany & Ming Chen, Denmark

Session 7: Carcinogenesis and stem cells (14.00 - 15.30)
Chair: Gabrielle Rieder & Johan Wandall, Denmark


H. pylori infection promotes intestinal inflammation and colon carcinogenesis in mice deficient in T-cell SMAD4.
John Nedrud, Cleveland, USA
Abstract presentations:

HP-18. A bacterial host CagL/avß5 integrin complex is responsible for Helicobacterpylori-induced precancerous condition.
Gabrielle Rieder, Salzburg, Austria.
HP-20. Evaluation of gene expression profile of chromatin modification enzymes in ACP02 and ACP03 gastric cell lines.
Juliana Santos, SP, Brazil.
HP-24. The carcinogenic bacterial pathogen Helicobacter pylori triggers DNA double strand breaks and a DNA damage response in infected host cells.
Mara Hartung, Zurich, Switzerland.
HP-40. Urokinase plasminogen activator receptor (uPAR) is upregulated in gastric mucosa in response to Helicobacter pylori infection in C57BL/6 mice.
Warner Alpízar-Alpízar, Copenhagen, Denmark.
HP-51. Helicobacter pylori and the BMP pathway regulate CDX2 and SOX2 expression in gastric cells.
Vânia Camilo, Porto, Portugal.

15.30: Coffee/Tea break

Session 8: Basic Mechanisms (16.00 - 17.30)
Chair: Karen Krogfelt, Denmark & Bow Ho, Singapore


Galectins and other carbohydrates (Title to be announced).
Gerardo Vasta, Baltimore, USA
Abstract presentations:

HP-32. Post-transcriptional control of gene expression in Helicobacter pylori: major role of the RNase J ribonuclease that is associated with the sole DExD-box RNA-helicase into an RNA-degradosome.
Hilde de Reuse, Paris, France.
HP-38. The nitroreductase FrxA protects Helicobacter pylori from nitrosative injury.
Margarida Parente, Oeiras, Portugal.
HP-43. Involvement of CagA EPIYA phosphorylation in the induction of IL-8 through the activation of TAK1 kinase.
K. Papadakos, Athens, Greece.
HP-57. A small regulatory RNA represses expression of the chemotaxis receptor TlpB.
Sandy Pernitzsch, Würzburg, Germany.
HP-58. In vitro suppression of Dendritic cells by Helicobacter pylori OipA.
O. Teymournejad, Tehran, Iran

18.00: Dinner

19.00: Business meeting for committees, Room B-21

20.00: Award committee meeting, Room B-21

20.00: Live music at Konventium

Saturday July 7, 2012

Session 9: Can we make a truly effective vaccine against H pylori? (08.30 - 09.30)
Chair: Mario D’Elios, Italy & Hanne Colding, Denmark

Pro: Markus Gerhard
Contra: Phil Sutton, Johan Wandall

09.30: Coffee/Tea Break

Young Scientist Awards (10.00 - 11.30)
Chair: Thomas Boren, Sweden & Leif P. Andersen, Denmark

Young Scientist awards (5 min presentations each):

Three best poster presentations
Three best oral presentations
The best presentations overall

Closing session (11.30 - 12.00)
Highlights 2012
Arnoud van Vliet, Norwich, UK
Close of the meeting
Leif P. Andersen, Denmark

12.00: Lunch / Departure

(only if ordered at time of registration on Wednesday, cost €10)


Poster sessions

Poster session 1
Chair: Torkel Wadström, Sweden & Christine Josenhans, Germany.

HP-02. Gastrointestinal in vitro models for infection studies resembling the in vivo human gastrointestinal tract.
Sara Lindén, Gothenburg, Sweden.
HP-15. Effect of H. pylori infection on GATA 5 and TFF1 regulation, in vivo and in vitro evidences.
Marisa Alvarez, SP, Brazil.
HP-22. Gastric mucin alterations associated with H. heilmannii sensu stricto infection.
Annemieke Smet, Ghent, Belgium.
HP-30. Helicobacter suis outer membrane vesicles and their influence on gastric epithelial cells.
Bram Flahou, Ghent, Belgium.
HP-59. Frequency of sialic acid binding adhesion gene in Helicobacter pylori isolated from Patient with Gastroduodenal Diseases.
Zahra Pakbaz, Thereran, Iran.
HP-60. Clinical prevalence of the Helicobacter pylori gene for blood-group antigen-binding adhesion.
Zahra Pakbaz, Thereran, Iran.
HP-74. Helicobacter pylori vacA and cagA related genes from diseases of the stomach at the Korle-Bu Teaching Hospital, Accra Ghana.
EK Aidoo, Korle-Bu, Ghana.

Poster session 2
Chair: Mario D’Elios, Italy & Dionyssios Sqouras, Greece.

HP-12. Systemic immunomodulation by Helicobacter pylori protects against allergic and chronic inflammatory disorders via tolerogenic re-programming of dendritic cells.
Anne Müller, Zurich, Switzerland.
HP-41. Leptin receptor signaling is an important regulator of both CD4+ T cell and Treg function in the gastric mucosa.
Anna Walduck, Melbourne, Australia.
HP-44. Immune cell Protease Activated Receptor 1 suppresses the cytokine and vaccine-induced protective response to Helicobacter pylori.
Philip Sutton, Melbourne, Australia.
HP-45. Transient depletion of regulatory T cells in the transgenic mice enhances local immune responses to Helicobacter pylori infection.
Sukanva Raghavan, Gothenburg, Sweden.
HP-49. Luminex® assay optimisation: a novel approach to characterising cytokineexpression profiles in human gastric biopsies in Helicobacter pylori infection.
Richard Ingram, Nottingham, UK.
HP-50. Are Th17 or Th1 cells dominant in human Helicobacter pylori infection?
Emily Staples, Nottingham, UK.
HP-54. Differentiating roles for interferon-γ and IL-17 in protection against Helicobacter pylori infection.
Louise Ottsjö, Gothenburg, Sweden.
HP-61. Analysis of comparative effect of IgY produced against UreC protein and UreCDNA vaccine on H. pylori infection in mice.
Ziba Malekshahi, Theheran, Iran.
HP-70. Helicobacter γGT dependent pathogenesis of epithelial cells.
Javed Sundus, Munich, Germany.
HP-79. Induction of miR-155 by Helicobacter pylori inhibits DNA-damage induced apoptosis.
Manuel Koch, Berlin, Germany.

Poster session 3
Chair: Hilde De Reuse, France & Henrik Permin, Denmark

HP-10. Xer-cise for markerless gene deletions in H. pylori.
Jonathan Gauntlett, Western Australia, Australia.
HP-17. In vivo sequence variation in HopZ, a phase variable outer membrane protein of Helicobacter pylori.
Lynn Kennemann, Hannover, Germany.
HP-21. Effects of Helicobacter pylori infection on MGMT and MLH1 promotermethylation status and microsatellite instability in paediatric and adult patients.
Marcelo Ribeiro, SP, Brazil.
HP-29. Helicobacter suis infection in a pig veterinarian.
Bram Flahou, Ghent, Belgium.
HP-35. Presence of viable Helicobacter suis bacteria in pork.
Bram Flahou, Ghent, Belgium.
HP-67. Microbial dysbiosis in pediatric patients with Crohn’s disease.
Hazel Mitchell, New South Wales, Australia.
HP-71. In vitro study of Helicobacter pylori interspecies interaction.
Y. Khosravi, Kuala Lumpur, Malaysia.
HP-73. Transcriptional features are rewired during genome evolution in the Epsilon-Proteobacteria.
Arnoud van Vliet, Norwich, UK.
HP-77. Extremely susceptibility of H. pylori to moxafloxacine as one of newly introduced fluroquinolones.
Amin Abadi, Theran, Iran.
HP-78. Clinical value of HopQI genotype of Helicobacter pylori; association withresistance phenomena.
Amin Abadi, Theran, Iran.

Poster session 4
Chair: Markus Gerhardt, Germany & Ming Chen, Denmark

HP-26. Consequences of Helicobacter pylori infection on mitochondria and their genome, relation with gastric pathogenesis.
Eliette Touati, Paris, France.
HP-31. A novel line blot system to detect an infection with pathogenic H. pylori.
Luca Formichella, Munich, Germany.
HP-53. L-proline transport and metabolism in Helicobacter pylori physiology.
Araceli Rivera-Ordaz, Munich, Germany.
HP-63. Molecular characterization of clarithromycin-resistant Helicobacter pylori among dyspeptic patients in Khartoum State.
Nazar Abdalsadeg, Omdurman, Sudan.
HP-65. PAR-1 polymorphisms and risk of gastric cancer in a Chinese population.
Hazel Mitchell, New South Wales, Australia.
HP-66. Pattern recognition receptors and Helicobacter pylori-related gastric cancer.
Hazel Mitchell, New South Wales, Australia.
HP-68. Changing Helicobacter pylori antibiotic resistance pattern in Malaysia.
XS The, Kuala Lumpur, Malaysia.
HP-76. Combined presence of the Helicobacter pylori jhp0562 and tnpA genes predict the presence of duodenal ulcer.
Amin Abadi, Theran, Iran.
HP-80. Esomeprazole treatment of type 2 diabetes patients decreased levels of H. pylori and raised HbA1c levels.
B. Smith, Copenhagen, Denmark.

4 Jul - 7 Jul 2012

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